| Identification | Back Directory | [Name]
TC-N 22A | [CAS]
1314140-00-5 | [Synonyms]
TC-N 22A
TCN 22A,TC N 22A
4,5,6,8-Tetrahydro-N-2-pyridinylpyrazolo[3',4':6,7]cyclohepta[1,2]thiazol-2-amine
N-pyridin-2-yl-4,5,6,7-tetrahydropyrazolo[2,3]cyclohepta[2,4-b][1,3]thiazol-2-amine
Pyrazolo[3',4':6,7]cyclohepta[1,2]thiazol-2-amine, 4,5,6,8-tetrahydro-N-2-pyridinyl- | [Molecular Formula]
C14H13N5S | [MDL Number]
MFCD22683816 | [MOL File]
1314140-00-5.mol | [Molecular Weight]
283.35 |
| Chemical Properties | Back Directory | [Boiling point ]
603.5±58.0 °C(Predicted) | [density ]
1.435±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble to 50 mM in DMSO | [form ]
Powder | [pka]
11.98±0.20(Predicted) |
| Hazard Information | Back Directory | [Uses]
TC-N 22A is a tricyclic thiazopyrazole derivative used as glutamate receptor 4 positive allosteric modulators used in the treatment of Parkinson’s disease, anxiety and pain. | [in vivo]
TC-N 22A (oral administration; 10 mg/kg) displays good plasma (259 ng/mL) and brain exposure levels (200 ng/mL) as well as good brain penetration (brain/plasma ratios of 0.8) after 1 h following a 10 mg/kg oral administration in SpragueDawley rats[1]. | [storage]
Store at -20°C |
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| Company Name: |
BOC Sciences
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| Tel: |
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| Website: |
https://www.bocsci.com |
| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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