| Identification | Back Directory | [Name]
BPO-27 (racemate) | [CAS]
1314873-02-3 | [Synonyms]
BPO-27 racemat
BPO-27 (racemate)
BPO 27 RACEMATE; BPO27 RACEMATE
Inhibitor,Cystic fibrosis transmembrane conductance regulator,inhibit,BPO27 racemate,Autophagy,BPO-27,BPO 27,BPO 27 racemate,BPO27,CFTR
6H-Pyrimido[4',5':3,4]pyrrolo[2,1-c][1,4]benzoxazine-2-carboxylic acid, 6-(5-bromo-2-furanyl)-7,8,9,10-tetrahydro-7,9-dimethyl-8,10-dioxo-11-phenyl- | [Molecular Formula]
C26H18BrN3O6 | [MOL File]
1314873-02-3.mol | [Molecular Weight]
548.34 |
| Chemical Properties | Back Directory | [Boiling point ]
732.9±70.0 °C(Predicted) | [density ]
1.68±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 6 mg/mL (10.94 mM) | [form ]
Solid | [pka]
3.76±0.40(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
BPO-27 racemate is a potent CFTR inhibitor with an IC50 of 8 nM. | [in vivo]
Following bolus interperitoneal administration in mice, serum (R)-1 decays with t1/2 ≈ 1.6 h and gives sustained therapeutic concentrations in kidney[1]. | [References]
[1] Snyder DS, et al. Absolute Configuration And Biological Properties of Enantiomers of CFTR Inhibitor BPO-27. ACS Med Chem Lett. 2013 May 9;4(5):456-459. DOI:10.1021/ml400069k
[2] Kim Y, et al. Benzopyrimido-pyrrolo-oxazine-dione (R)-BPO-27 Inhibits CFTR Chloride Channel Gating by Competition with ATP. Mol Pharmacol. 2015 Oct;88(4):689-96. DOI:10.1124/mol.115.098368 |
|
| Company Name: |
BOC Sciences
|
| Tel: |
|
| Website: |
https://www.bocsci.com |
|