| Identification | Back Directory | [Name]
MMV-390048 | [CAS]
1314883-11-8 | [Synonyms]
MMV 048
MMV-390048
[3,3'-Bipyridin]-2-amine, 5-[4-(methylsulfonyl)phenyl]-6'-(trifluoromethyl)-
MMV-390048,inhibit,PI4 kinases,Parasite,Inhibitor,MMV390048,MMV 390048,Phosphatidylinositol 4 kinases,PI4K | [Molecular Formula]
C18H14F3N3O2S | [MDL Number]
MFCD28502126 | [MOL File]
1314883-11-8.mol | [Molecular Weight]
393.38 |
| Chemical Properties | Back Directory | [Boiling point ]
534.4±50.0 °C(Predicted) | [density ]
1.385±0.06 g/cm3(Predicted) | [storage temp. ]
4°C, protect from light | [solubility ]
DMSO : 100 mg/mL (254.21 mM; Need ultrasonic) | [form ]
Solid | [pka]
3.79±0.50(Predicted) | [color ]
White to off-white | [InChI]
InChI=1S/C18H14F3N3O2S/c1-27(25,26)14-5-2-11(3-6-14)13-8-15(17(22)24-10-13)12-4-7-16(23-9-12)18(19,20)21/h2-10H,1H3,(H2,22,24) | [InChIKey]
RTJQABCNNLMCJF-UHFFFAOYSA-N | [SMILES]
C1(N)=NC=C(C2=CC=C(S(C)(=O)=O)C=C2)C=C1C1=CC=C(C(F)(F)F)N=C1 |
| Hazard Information | Back Directory | [Uses]
MMV390048 is a representative of a new chemical class of Plasmodium PI4K inhibitor (Kdapp=0.3 μM). MMV390048 binds to the ATP binding site of Plasmodium PI4K and does not bind to other P. falciparum and human kinases apart from human PIP4K2C, thus alleviating potential kinase-mediated safety concerns. MMV390048 is an antimalarial agent[1]. | [IC 50]
Plasmodium | [References]
[1] Paquet T, et al. Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase. Sci Transl Med. 2017 Apr 26;9(387). pii: eaad9735. DOI:10.1126/scitranslmed.aad9735 |
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