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1315330-11-0

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1315330-11-0 Structure

1315330-11-0 Structure
IdentificationBack Directory
[Name]

BenzaMide, N-[4-[(4-ethyl-1-piperazinyl)Methyl]-3-(trifluoroMethyl)phenyl]-4-Methyl-3-[(6-Methyl-7H-pyrrolo[2,3-d]pyriMidin-4-yl)oxy]-
[CAS]

1315330-11-0
[Synonyms]

CS-1492
AK122840
HY-77251
AKOS016012030
SureCN14689441
TAK1/MAP4K2 INHIBITOR 1
B-Raf inhibitor (BenzaMide)
TAK1/MAP4K2 inhibitor 1,TAK-1/MAP4K2 inhibitor 1
1315330-11-0; SURECN14689441; AKOS016012030; B-RAF INHIBITOR;1315330-11-0; CS-1099; AK122840; HY-77251
N-[4-[(4-Ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-[(6-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy]benzamide
BenzaMide, N-[4-[(4-ethyl-1-piperazinyl)Methyl]-3-(trifluoroMethyl)phenyl]-4-Methyl-3-[(6-Methyl-7H-pyrrolo[2,3-d]pyriMidin-4-yl)oxy]-
[Molecular Formula]

C29H31F3N6O2
[MDL Number]

MFCD22572824
[MOL File]

1315330-11-0.mol
[Molecular Weight]

552.59
Chemical PropertiesBack Directory
[density ]

1.319±0.06 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

DMSO : 50 mg/mL (90.48 mM; Need ultrasonic)
[form ]

Powder
[pka]

12.43±0.50(Predicted)
[color ]

White to off-white
Safety DataBack Directory
[Symbol(GHS) ]

Exclamation Mark (GHS07)
GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H315-H319-H335
[Precautionary statements ]

P261-P280-P301+P312-P302+P352-P305+P351+P338
[HS Code ]

2922500090
Hazard InformationBack Directory
[Uses]

TAK1/MAP4K2 inhibitor 1 is a potent dual TGFβ-activated kinase 1 (TAK1) and mitogen-activated protein kinase kinase kinase kinase 2 (MAP4K2) inhibitor, with IC50s of 41.1 nM and 18.2 nM, respectively.
[in vivo]

TAK1/MAP4K2 inhibitor 1 has moderate terminal elimination half-life (t1/2=2.94 h for mice (1 mg/kg, iv))[1].

[IC 50]

TAK1: 41.1 nM (IC50); MAP4K2: 18.2 nM (IC50)
[storage]

Store at -20°C
[References]

[1] Tan L, et al. Discovery of type II inhibitors of TGFβ-activated kinase 1 (TAK1) and mitogen-activated protein kinase kinase kinase kinase 2 (MAP4K2). J Med Chem. 2015 Jan 8;58(1):183-96. DOI:10.1021/jm500480k
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