ChemicalBook--->CAS DataBase List--->1322001-35-3

1322001-35-3

Request For Quotation
1322001-35-3 Structure

1322001-35-3 Structure
IdentificationBack Directory
[Name]

PF4455242 hydrochloride
[CAS]

1322001-35-3
[Synonyms]

PF 4455242,PF4455242
PF4455242 hydrochloride
PF-4455242 hydrochloride
PF 4455242 hydrochloride
PF04455242 hydrochloride
PF 04455242 hydrochloride
PF-04455242 (hydrochloride)
PF-04455242 hydrochloride >=98% (HPLC)
2-methyl-N-((2'-(pyrrolidin-1-ylsulfonyl)-[1,1'-biphenyl]-4-yl)methyl)propan-1-amine
2-METHYL-N-((2'-(PYRROLIDIN-1-YLSULFONYL)-[1,1'-BIPHENYL]-4-YL)METHYL)PROPAN-1-AMINE HCL
2-Methyl-N-((2′-(pyrrolidin-1-ylsulfonyl)biphenyl-4-yl)methyl)propan-1-amine hydrochloride
N-(2-Methylpropyl)-2′-(1-pyrrolidinylsulfonyl)-[1,1′-biphenyl]-4-methanamine hydrochloride
[Molecular Formula]

C21H29ClN2O2S
[MDL Number]

MFCD22666388
[MOL File]

1322001-35-3.mol
[Molecular Weight]

408.99
Chemical PropertiesBack Directory
[storage temp. ]

room temp
[solubility ]

DMSO: soluble5mg/mL (clear solution, warmed)
[form ]

powder
[color ]

white to beige
Safety DataBack Directory
[WGK Germany ]

3
Hazard InformationBack Directory
[Uses]

PF-4455242 hydrochloride is a selective, short-acting antagonist of the κ-opioid receptor, exhibiting potential analgesic effects. PF-4455242 hydrochloride has been identified through a strategy utilizing parallel chemistry and physicochemical property design. PF-4455242 hydrochloride demonstrated confirmed potency and selectivity in the tail-flick analgesia model.
[Biological Activity]

PF-4455242 is a selective k opioid receptor (KOR) antagonist with 20-fold selectivity for kappa over mu receptors (k Ki = 3 nMμ Ki =64 nM). PF-4455242 is orally activehas good brain penetration in rats and was able to block the effects of the kappa agonist U50488. Studies indicate th at k blockade has afforded antidepressant activity in several animal models. PF-4455242 has been in phase I clinical trials for trial for bipolar depression.
[References]

[1] Design and discovery of a selective small molecule κ opioid antagonist (2-methyl-N-((2'-(pyrrolidin-1-ylsulfonyl)biphenyl-4-yl)methyl)propan-1-amine, PF-4455242)
Spectrum DetailBack Directory
[Spectrum Detail]

PF4455242 hydrochloride(1322001-35-3)1HNMR
1322001-35-3 suppliers list
Company Name: AstaTech (Chengdu) Pharma. Co., Ltd.  
Telephone: 15928766785 15928766785
Website: http://www.astabiochem.cn/
Company Name: Shanghai Tombiopharma Chemical Co. Ltd.  
Telephone: 13391076197
Website: http://www.tombiopharma.com
Company Name: SPIRO PHARMA  
Telephone:
Website: www.spiropharma.com.cn
Company Name: Baoji Guokang Healthchem co.,ltd  
Telephone: +8615604608665 15604608665
Website: www.gk-bio.com
Company Name: AFINE CHEMICALS LIMITED  
Telephone: +86-571-85134551 +86-18958018566
Website: www.afinechem.com/index.html
Company Name: HANGZHOU CLAP TECHNOLOGY CO.,LTD  
Telephone: 86-571-88216897,88216896 13588875226
Website: www.hzclap.com/en
Company Name: Jingmo (Xiamen) Biotechnology Co., Ltd  
Telephone: 13621943973; 13621943973
Website: http://www.jamxmpharmatech.com/
Company Name: career henan chemical co  
Telephone: +86-0371-86658258
Website: www.coreychem.com
Company Name: Chengdu Jiuding Chemical Technology Co., Ltd. - Song Bo  
Telephone: 18584079237
Website: www.chemicalbook.com/ShowSupplierProductsList1150985/0_EN.htm
Company Name: Energy Chemical  
Telephone: 400-0056266
Website: www.energy-chemical.com
Company Name: Wuhan Topule  
Telephone: +86-02787215551 19945035818
Website: http://www.topule.com/
Company Name: AstaTech(Chengdu) Biopharmaceutical Corp.  
Telephone: 028-82666846 18080826311
Website: http://www.astatech.com.cn/
Company Name: Nanjing Wogni Chemical Co., Ltd.  
Telephone: 15996452985
Website: www.chemicalbook.com/ShowSupplierProductsList775095/0_EN.htm
Company Name: TargetMol Chemicals Inc.  
Telephone: 4008200310 15002144251
Website: https://www.targetmol.cn/
Company Name: Jinan Guangchen Pharmaceutical Technology Co., Ltd  
Telephone: 18563726319
Website: https://www.chemicalbook.com/supplier/24863567/
Company Name: Jining Yize Pharmaceutical Technology Co., Ltd  
Telephone: 15192473210
Website:
Company Name: Nanjing Shizhou Biology Technology Co.,Ltd  
Telephone: 025-85560043 15850508050
Website: http://www.synzest.com
Company Name: Shanghai Amole Biotechnology Co., Ltd.  
Telephone: 13370042665 18916960931
Website: www.amole.com.cn/
Tags:1322001-35-3 Related Product Information
50354-99-9 1322001-35-3 71398-49-7