| Identification | More | [Name]
Neohesperidin | [CAS]
13241-33-3 | [Synonyms]
HESPERETIN-7-NEOHESPERIDOSIDE
HESPERETIN-7-O-NEOHESPERIDOSIDE
NEOHESPERIDIN
NEOHESPERIDIN (PR)
(S)-4'-METHOXY-3',5,7-TRIHYDROXYFLAVONE-7-[2-O-(ALPHA-L-RHAMNOPYRANOSYL)-BETA-D-GLUCOPYRANOSIDE]
(S)-7-(((2-O-6-Deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl)oxy)-2,3-dihydro-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one
(s)-a-d-glucopyranosyl)oxy)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)
4h-1-benzopyran-4-one,2,3-dihydro-7-((2-o-(6-deoxy-alpha-l-mannopyranosyl)-bet
(S)-7-[[2-O-6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl]oxy]-2,3-dihydro-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one
Neohesperdin
(s)-4'-methoxy-3',5,7-trihydroxyflavanone-7-[2-o-(α-l-rhamnopyranosyl)-β-d-glucopyranoside]
NEOHESPERIDIN WITH HPLC
HESPERETIN-7-NEOHESPERIDOSIDE hplc
(S)-7-(((2-O-6-Deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl)oxy)-2,3-dihydro-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one
rhamnopyranosyl-(1→2)-β-D-glucopyranoside
Neohesperidin，Hesperetin 7-neohesperidoside
(2S)-2-(3-Hydroxy-4-methoxyphenyl)-5-hydroxy-7-(2-O-α-L-rhamnopyranosyl-β-D-glucopyranosyloxy)-2,3-dihydro-4H-1-benzopyran-4-one
(2S)-7-[[2-O-(6-Deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-2,3-dihydro-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one | [EINECS(EC#)]
236-216-9 | [Molecular Formula]
C28H34O15 | [MDL Number]
MFCD00017357 | [Molecular Weight]
610.56 | [MOL File]
13241-33-3.mol |
| Chemical Properties | Back Directory | [Melting point ]
239-243°C | [Boiling point ]
933.7±65.0 °C(Predicted) | [density ]
1.65±0.1 g/cm3(Predicted) | [vapor pressure ]
0Pa at 20℃ | [storage temp. ]
2-8°C
| [solubility ]
DMSO (Slightly), Pyridine (Slightly) | [form ]
neat | [pka]
7.14±0.40(Predicted) | [color ]
White to Off-White | [biological source]
plant (orange) | [Water Solubility ]
3.98mg/L at 20℃ | [BRN ]
74945 | [InChIKey]
ARGKVCXINMKCAZ-RTFRIYMLSA-N | [LogP]
-0.69 at 20℃ | [CAS DataBase Reference]
13241-33-3(CAS DataBase Reference) |
| Safety Data | Back Directory | [Safety Statements ]
S22:Do not breathe dust .
S24/25:Avoid contact with skin and eyes . | [WGK Germany ]
3
| [RTECS ]
DJ2981400
| [F ]
10-21 | [HS Code ]
29389090 |
| Hazard Information | Back Directory | [Description]
Neohesperidin is a flavonoid found in citrus fruit peel that has diverse biological activities.1,2,3 In vitro, it inhibits osteoclast differentiation, bone resorption, calcium oscillations, and activation of NF-κB and nuclear factor of activated T cells (NFAT) by receptor activator of NF-κB ligand (RANKL).1 In vivo, neohesperidin administration protects ovariectomized mice from bone loss. Neohesperidin acts as a hypolipidemic agent, reducing lipid accumulation in HepG2 cells and reversing hyperlipidemia in a mouse model of diet-induced obesity.2 In a mouse model of diabetes, neohesperidin increases glucose tolerance and decreases insulin resistance while simultaneously decreasing serum triglycerides and total cholesterol and inhibiting lipid accumulation in livers in vivo.3 | [Chemical Properties]
White powder | [Uses]
An antioxidant flavanone glycoside | [Uses]
Neohesperidin can be used in cosmetic products and as a sweetening agent in food & beverages, an antioxidant flavanone glycoside
| [Uses]
Neohesperidin exhibits lipid-regulating effects in vivo and in vitro. It is a main flavonoid in citrus byproducts (CBP) which possesses anti-oxidant activity. | [Definition]
ChEBI: A flavanone glycoside that is hesperitin having an 2-O-(alpha-L-rhamnopyranosyl)-beta-D-glucopyranosyl moiety attached to the 7-hydroxy group. | [Flammability and Explosibility]
Notclassified | [References]
[1] ZHEN TAN . Neohesperidin suppresses osteoclast differentiation, bone resorption and ovariectomised-induced osteoporosis in mice[J]. Molecular and Cellular Endocrinology, 2017, 439: Pages 369-378. DOI: 10.1016/j.mce.2016.09.026
[2] HAOSHU WU. Neohesperidin Exerts Lipid-Regulating Effects in vitro and in vivo via Fibroblast Growth Factor 21 and AMP-Activated Protein Kinase/Sirtuin Type 1/Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1α Signaling Axis.[J]. Pharmacology, 2017, 100 3-4: 115-126. DOI: 10.1159/000452492
[3] JIA S, HU Y, ZHANG W, et al. Hypoglycemic and hypolipidemic effects of neohesperidin derived from Citrus aurantium L. in diabetic KK-Ay mice[J]. Food & Function, 2015, 3: 878-886. DOI: 10.1039/c4fo00993b |
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