| Identification | Back Directory | [Name]
(LEU31,PRO34)-NEUROPEPTIDE Y (HUMAN, RAT) | [CAS]
132699-73-1 | [Synonyms]
[LEU31,PRO34] NPY, HUMAN
(LEU31,PRO34)-NPY (HUMAN, RAT)
M.W. 4240.67 C189H284N54O56S
[LEU31,PRO34] NEUROPEPTIDE Y, HUMAN
YPSKPDNPGEDAPAEDMARYYSALRHYINLLTRPRY-NH2
(LEU31,PRO34)-NEUROPEPTIDE Y (HUMAN, RAT)
TYR-PRO-SER-LYS-PRO-ASP-ASN-PRO-GLY-GLU-ASP-ALA-PRO-ALA-GLU-ASP-MET-ALA-ARG-TYR-TYR-SER-ALA-LEU-ARG-HIS-TYR-ILE-ASN-LEU-LEU-THR-ARG-PRO-ARG-TYR-NH2
H-TYR-PRO-SER-LYS-PRO-ASP-ASN-PRO-GLY-GLU-ASP-ALA-PRO-ALA-GLU-ASP-MET-ALA-ARG-TYR-TYR-SER-ALA-LEU-ARG-HIS-TYR-ILE-ASN-LEU-LEU-THR-ARG-PRO-ARG-TYR-NH2
TYR-PRO-SER-LYS-PRO-ASP-ASN-PRO-GLY-GLU-ASP-ALA-PRO-ALA-GLU-ASP-LEU-ALA-ARG-TYR-TYR-SER-ALA-LEU-ARG-HIS-TYR-ILE-ASN-LEU-LEU-THR-ARG-PRO-ARG-TYR-NH2: YPSKPDNPGEDAPAEDLARYYSALRHYINLLTRPRY-NH2 | [Molecular Formula]
C189H284N54O56S | [MDL Number]
MFCD00132605 | [MOL File]
132699-73-1.mol | [Molecular Weight]
4240.67 |
| Chemical Properties | Back Directory | [storage temp. ]
−20°C
| [solubility ]
Soluble in DMSO | [form ]
Powder | [Water Solubility ]
Soluble to 1 mg/ml in water | [Sequence]
Tyr-Pro-Ser-Lys-Pro-Asp-Asn-Pro-Gly-Glu-Asp-Ala-Pro-Ala-Glu-Asp-Met-Ala-Arg-Tyr-Tyr-Ser-Ala-Leu-Arg-His-Tyr-Ile-Asn-Leu-Leu-Thr-Arg-Pro-Arg-Tyr-NH2 |
| Hazard Information | Back Directory | [Uses]
[Leu31,Pro34]-Neuropeptide Y(human,rat) is a specific neuropeptide Y Y1 receptor agonist. [Leu31,Pro34]-Neuropeptide Y(human,rat) slao activates Y4, Y5. [Leu31,Pro34]-Neuropeptide Y(human,rat) can increase blood pressure in anesthetized rats and increases food intake[1][2]. | [in vivo]
[Leu31,Pro34]-Neuropeptide Y(human,rat) (30 pmol; microinjected into paraventricular nucleus) increases food intake in the rats (350±400 g)[3]. | [IC 50]
NPY Y1 receptor; NPY Y4 receptor; NPY Y5 receptor | [storage]
Store at -20°C | [References]
[1] J Fuhlendorff, et al. [Leu31, Pro34]neuropeptide Y: a specific Y1 receptor agonist. Proc Natl Acad Sci U S A. 1990 Jan;87(1):182-6. DOI:10.1073/pnas.87.1.182
[2] K McCrea, et al. 2-36[K4,RYYSA(19-23)]PP a novel Y5-receptor preferring ligand with strong stimulatory effect on food intake. Regul Pept. 2000 Feb 8;87(1-3):47-58. DOI:10.1016/s0167-0115(99)00108-1
[3] A Kask, et al. Evidence for involvement of neuropeptide Y receptors in the regulation of food intake: studies with Y1-selective antagonist BIBP3226. Br J Pharmacol. 1998 Aug;124(7):1507-15. DOI:10.1038/sj.bjp.0701969 |
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