| Identification | Back Directory | [Name]
Azvudine hydrochloride | [CAS]
1333126-31-0 | [Synonyms]
FNChydrochloride
RO-0622 hydrochloride
Azvudine hydrochloride
2(1H)-Pyrimidinone,4-amino-1-(4-C-azido-2-deoxy-2-fluoro-β-D-arabinofuranosyl)-,hydrochloride(1:1) | [Molecular Formula]
C9H12ClFN6O4 | [MOL File]
1333126-31-0.mol | [Molecular Weight]
322.68 |
| Hazard Information | Back Directory | [Uses]
Azvudine (RO-0622) hydrochloride is a potent nucleoside reverse transcriptase inhibitor (NRTI), with antiviral activity on HIV, HBV and HCV. Azvudine hydrochloride exerts highly potent inhibition on HIV-1 (EC50s ranging from 0.03 to 6.92 nM) and HIV-2 (EC50s ranging from 0.018 to 0.025 nM). Azvudine hydrochloride inhibits NRTI-resistant viral strains[1]. Azvudine (hydrochloride) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | [IC 50]
HIV-1: 0.03-6.92 nM (EC50); HIV-2: 0.018-0.02 nM (EC50) | [References]
[1] Wang RR, et al. Azvudine, a novel nucleoside reverse transcriptase inhibitor showed good drug combination features and better inhibition on drug-resistant strains than lamivudine in vitro. PLoS One. 2014 Aug 21;9(8):e105617. DOI:10.1371/journal.pone.0105617 |
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