ChemicalBook--->CAS DataBase List--->1333207-63-8

1333207-63-8

1333207-63-8 Structure

1333207-63-8 Structure
IdentificationBack Directory
[Name]

TRPC6 inhibitor
[CAS]

1333207-63-8
[Synonyms]

CPA-1588
TRPC6 inhibitor
SAR7334 (hydrochloride)
SAR7334 dihydrochloride
TRCP6 inhibitor(SAR7334)
CPA-1588(dihydrochloride)
TRCP6-IN-1 (hydrochloride)
TRCP 6 INHIBITOR;SAR 7334;SAR-7334
SAR7334 HYDROCHLORIDE ;TRCP 6 INHIBITOR
4-{[(1R,2R)-2-[(3R)-3-Aminopiperidin-1-yl]-2,3-dihydro-1H-inden-1-yl]oxy}-3-chlorobenzonitrile
4-[[(1R,2R)-2-[(3R)-3-Amino-1-piperidinyl]-2,3-dihydro-1H-inden-1-yl]oxy]-3-chlorobenzonitrile dihydrochloride
4-[[(1R,2R)-2-[(3R)-3-Amino-1-piperidinyl]-2,3-dihydro-1H-inden-1-yl]oxy]-3-chlorobenzonitrile hydrochloride (1:2)
[Molecular Formula]

C21H24Cl3N3O
[MDL Number]

MFCD27992059
[MOL File]

1333207-63-8.mol
[Molecular Weight]

440.794
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[solubility ]

Soluble in DMSO
[form ]

Powder
[color ]

White to yellow
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H315-H319-H335
[Precautionary statements ]

P261-P280-P301+P312-P302+P352-P305+P351+P338
Hazard InformationBack Directory
[Uses]

SAR 7334 is a TRCP6 inhibitor with potential for inhibiting pathological cardiac hypertrophy.
[in vivo]

SAR7334 (10?mg/kg, p.o.) suppresses TRPC6-dependent acute HPV in isolated perfused lungs from mice. SAR7334 demonstrates that it is suitable for chronic oral administration. In an initial short-term study, SAR7334 does not change mean arterial pressure in spontaneously hypertensive rats (SHR)[3].

[storage]

Store at -20°C
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1696-17-9

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