| Identification | Back Directory | [Name]
Benzonitrile, 4-[[(1R,2R)-2-[(3R)-3-aMino-1-piperidinyl]-2,3-dihydro-1H-inden-1-yl]oxy]-3-chloro- | [CAS]
1333210-07-3 | [Synonyms]
SAR7334
TRCP6-IN-1
TRCP6 inhibitor
4-(((1R,2R)-2-((R)-3-Aminopiperidin-1-yl)-2,3-dihydro-1H-inden-1-yl)oxy)-3-chlorobenzonitrile
Benzonitrile, 4-[[(1R,2R)-2-[(3R)-3-aMino-1-piperidinyl]-2,3-dihydro-1H-inden-1-yl]oxy]-3-chloro- | [Molecular Formula]
C21H22ClN3O | [MOL File]
1333210-07-3.mol | [Molecular Weight]
367.87 |
| Chemical Properties | Back Directory | [Boiling point ]
534.6±50.0 °C(Predicted) | [density ]
1.30±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
insoluble in H2O; ≥106.4 mg/mL in EtOH; ≥125.4 mg/mL in DMSO | [form ]
Solid | [pka]
10.95±0.20(Predicted) | [color ]
Light yellow to yellow | [InChIKey]
RLKRLNQEXBPQGQ-OZOXKJRCSA-N | [SMILES]
Clc1c(ccc(c1)C#N)O[C@H]2[C@@H](Cc4c2cccc4)N3C[C@@H](CCC3)N |
| Hazard Information | Back Directory | [Uses]
SAR7334 is a potent and specific TRPC6 inhibitor, inhibiting TRPC6 currents with IC50 of 7.9 nM. | [Biological Activity]
sar7334 is a potent trpc6(transient receptor potential cation channel, subfamily c, member 6) inhibitor. | [in vivo]
SAR7334 (10?mg/kg, p.o.) suppresses TRPC6-dependent acute HPV in isolated perfused lungs from mice. SAR7334 demonstrates that it is suitable for chronic oral administration. In an initial short-term study, SAR7334 does not change mean arterial pressure in spontaneously hypertensive rats (SHR)[3]. | [References]
[1] Ilatovskaya DV, et al. The Role of Angiotensin II in Glomerular Volume Dynamics and Podocyte Calcium Handling. Sci Rep. 2017 Mar 22;7(1):299. DOI:10.1038/s41598-017-00406-2
[2] Chauvet S, et al. Pharmacological Characterization of the Native Store-Operated Calcium Channels of Cortical Neurons from Embryonic Mouse Brain. Front Pharmacol. 2016 Dec 12;7:486. DOI:10.3389/fphar.2016.00486
[3] Maier T, et al. Discovery and pharmacological characterization of a novel potent inhibitor of diacylglycerol-sensitive TRPC cation channels. Br J Pharmacol. 2015 Jul;172(14):3650-60. DOI:10.1111/bph.13151 |
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| Company Name: |
SPIRO PHARMA
|
| Telephone: |
|
| Website: |
www.spiropharma.com.cn |
| Company Name: |
Wuhan Topule
|
| Telephone: |
+86-02787215551 19945035818 |
| Website: |
http://www.topule.com/ |
| Company Name: |
Bide Pharmatech Ltd.
|
| Telephone: |
400-1647117 13681763483 |
| Website: |
https://www.bidepharm.com/ |
|