| Identification | Back Directory | [Name]
Bis-PEG5-PFP ester | [CAS]
1334177-78-4 | [Synonyms]
PFP-PEG5-PFP
Bis-PEG5-PFP ester
Bis-PEG6-PFP ester
PEG5 BIS-PFP ESTER
Bis-dPEG(R)5-PFP ester
4,7,10,13,16-Pentaoxanonadecanedioic acid, 1,19-bis(2,3,4,5,6-pentafluorophenyl) ester | [Molecular Formula]
C26H24F10O9 | [MDL Number]
MFCD18916983 | [MOL File]
1334177-78-4.mol | [Molecular Weight]
670.45 |
| Chemical Properties | Back Directory | [Boiling point ]
606.0±55.0 °C(Predicted) | [density ]
1.443±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
Soluble in DMSO, DCM, DMF | [form ]
solid or viscous liquid |
| Hazard Information | Back Directory | [Description]
Bis-PEG5-PFP ester is a PEG linker containing two PFP ester moieties. PFP esters are activated esters which react with primary amines to form stable amide bonds. The hydrophilic PEG linker increases the water solubility of compounds in aqueous media. | [Uses]
Bis-PEG5-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [reaction suitability]
reagent type: cross-linking reagent
reactivity: amine reactive | [IC 50]
PEGs; Alkyl/ether | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. DOI:10.1016/j.ebiom.2018.09.005 |
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