| Identification | Back Directory | [Name]
Bis-PEG4-PFP ester | [CAS]
1314378-12-5 | [Synonyms]
PFP-PEG4-PFP
PEG4 BIS-PFP ESTER
Bis-PEG4-PFP ester
Di(Perfluorophenyl) 4,7,10,13-Tetraoxahexadecanedioate
Bis(perfluorophenyl) 4,7,10,13-tetraoxahexadecane-1,16-dioate
4,7,10,13-Tetraoxahexadecanedioic acid, 1,16-bis(2,3,4,5,6-pentafluorophenyl) ester | [Molecular Formula]
C24H20F10O8 | [MDL Number]
MFCD21363293 | [MOL File]
1314378-12-5.mol | [Molecular Weight]
626.39 |
| Chemical Properties | Back Directory | [Boiling point ]
570.5±50.0 °C(Predicted) | [density ]
1.473±0.06 g/cm3(Predicted) | [storage temp. ]
Storage temp. 2-8°C | [solubility ]
Soluble in DCM | [form ]
Liquid | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Description]
Bis-PEG4-PFP ester is a PEG linker with two terminal PFP ester moieties. PFP esters are activated esters that react with primary amines to form amide bonds. They have been found to be more stable than other amine reactive groups because they are less likely to undergo hydrolysis. The hydrophilic PEG linker increases the water solubility of the compound in aqueous media. | [Uses]
Bis-PEG4-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs; Alkyl/ether | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. DOI:10.1016/j.ebiom.2018.09.005 |
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