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SC 51316 is a nonpeptidic angiotensin II (AII) receptor antagonist. | [Uses]
SC-51316 is an oral active angiotensin II receptor antagonist with the IC50 values of 3.6 and 5.1 nM in rat adrenal cortical and rat uterine membrane, respectively. SC-51316 shows antihypertensive activity in vivo and in vitro[1][2]. | [References]
[1] Olins GM, et al. In vitro pharmacology of a nonpeptidic angiotensin II receptor antagonist, SC-51316. J Pharmacol Exp Ther. 1992;261(3):1037-1043. PMID:1602371
[2] Olins GM, et al. In vivo pharmacology of SC-51316, a nonpeptidic angiotensin II receptor antagonist. Am J Hypertens. 1993;6(7 Pt 1):619-625. DOI:10.1093/ajh/6.7.619 |
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