| Identification | Back Directory | [Name]
PERK-IN-2 | [CAS]
1337531-83-5 | [Synonyms]
PERK-IN-2
PERKIN2,PERK IN 2
7-methyl-5-{1-[(2,3,5-trifluorophenyl)acetyl]-2,3-dihydro-1H-indol-5-yl}-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Ethanone, 1-[5-(4-amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2,3-dihydro-1H-indol-1-yl]-2-(2,3,5-trifluorophenyl)- | [Molecular Formula]
C23H18F3N5O | [MDL Number]
MFCD34469700 | [MOL File]
1337531-83-5.mol | [Molecular Weight]
437.42 |
| Chemical Properties | Back Directory | [Boiling point ]
726.8±60.0 °C(Predicted) | [density ]
1.49±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
5.76±0.30(Predicted) | [color ]
Off-white to light brown |
| Hazard Information | Back Directory | [Uses]
PERK-IN-2 is a potent PERK inhibitor with an IC50 of 0.2 nM[1]. | [References]
[1] Axten JM , et al. Discovery of 7-methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a potent and selective first-in-class inhibitor of protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK). J Med Chem. 2012 Aug 23;55(16):7193-207. DOI:10.1021/jm300713s |
|
| Company Name: |
cjbscvictory
|
| Tel: |
13348960310 13348960310; |
| Website: |
https://www.weikeqi-biotech.com/ |
|