| Hazard Information | Back Directory | [Description]
RO5488608 is a new potent mGlu2/3 NAM. | [Uses]
RO5488608 is a negative allosteric metabotropic modulator of glutamate receptor 2/3. RO5488608 inhibits LY354740 (HY-18941)-induced intracellular Ca2+ release and can be used for study of antidepressant[1]. | [References]
[1] Lundstr?m L, et al. Structural determinants of allosteric antagonism at metabotropic glutamate receptor 2: mechanistic studies with new potent negative allosteric modulators. Br J Pharmacol. 2011;164(2b):521-537. DOI:10.1111/j.1476-5381.2011.01409.x |
|
|