| Identification | Back Directory | [Name]
CFI-400936 | [CAS]
1338793-07-9 | [Synonyms]
CFI-400936
2-(dimethylamino)-2-(2-ethylphenyl)-N-[3-(3-sulfamoylphenyl)-1H-indazol-5-yl]acetamide
Benzeneacetamide, N-[3-[3-(aminosulfonyl)phenyl]-1H-indazol-5-yl]-α-(dimethylamino)-2-ethyl- | [Molecular Formula]
C25H27N5O3S | [MOL File]
1338793-07-9.mol | [Molecular Weight]
477.58 |
| Hazard Information | Back Directory | [Description]
CFI-400936 is a potent and selective TTK inhibitor with potential anticancer activity. This potent inhibitor of TTK (IC50=3.6nM) demonstrated good activity in cell based assay and selectivity against a panel of human kinases. | [Uses]
CFI-400936 is a potent TTK inhibitor with an IC50 of 3.6 nM. CFI-400936 has antitumor activity[1]. | [References]
[1] Laufer R, et al. Discovery of inhibitors of the mitotic kinase TTK based on N-(3-(3-sulfamoylphenyl)-1H-indazol-5-yl)-acetamides and carboxamides. Bioorg Med Chem. 2014 Sep 1;22(17):4968-97. DOI:10.1016/j.bmc.2014.06.027 |
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| Company Name: |
BOC Sciences
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| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
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