| Identification | Back Directory | [Name]
aciculatin | [CAS]
134044-97-6 | [Synonyms]
aciculatin
4H-1-Benzopyran-4-one, 8-(2,6-dideoxy-β-D-ribo-hexopyranosyl)-5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy- | [Molecular Formula]
C22H22O8 | [MOL File]
134044-97-6.mol | [Molecular Weight]
414.41 |
| Hazard Information | Back Directory | [Description]
Aciculatin, a natural compound extracted from the medicinal herb Chrysopogon aciculatus, shows potent anti-cancer potency. Aciculatin treatment induces cell cycle arrest and apoptosis via inhibition of MDM2 expression, thereby inducing p53 accumulation without significant DNA damage and genome toxicity. | [Uses]
Aciculatin is a compound with cytotoxic, anti-inflammatory and anti-arthritic activities, and its synthetic route including specific chemical reaction steps was determined through the first total synthesis. | [Definition]
ChEBI: Aciculatin is a member of flavonoids and a C-glycosyl compound. | [References]
[1] Total Synthesis of the Naturally Occurring Glycosylflavone Aciculatin DOI:10.1021/acs.jnatprod.5b01051 |
|
|