| Identification | Back Directory | [Name]
2'-deoxy-4'-thiocytidine | [CAS]
134111-30-1 | [Synonyms]
4′-thio-2-deoxycytidine
4’-thio-2’-deoxycytidine
2'-deoxy-4'-thiocytidine
Cytidine, 2'-deoxy-4'-thio- | [Molecular Formula]
C9H13N3O3S | [MOL File]
134111-30-1.mol | [Molecular Weight]
243.28 |
| Hazard Information | Back Directory | [Uses]
2′-Deoxy-4′-thiocytidine (T-dCyd) is a novel epigenetic agent. 2′-Deoxy-4′-thiocytidine administrations led to a significant p21 increase. 2′-Deoxy-4′-thiocytidine can eradicate of tumor cells in the double-mutant xenografts[1]. | [References]
[1] Sherry X Yang, et al. TET2 and DNMT3A mutations and exceptional response to 4'-thio-2'-deoxycytidine in human solid tumor models. J Hematol Oncol. 2021, 14, 1. DOI:10.1186/s13045-021-01091-5 |
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