| Identification | Back Directory | [Name]
Pentixafor | [CAS]
1341207-62-2 | [Synonyms]
CPCR4-2
Pentixafor
1,4,7,10-Tetraazacyclododecane-1,4,7-triacetic acid, 10-[2-[[[4-[[[3-[(2R,5S,8S,14R)-5-[3-[(aminoiminomethyl)amino]propyl]-14-[(4-hydroxyphenyl)methyl]-1-methyl-8-(2-naphthalenylmethyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaazacyclopentadec-2-yl]propyl]amino]carbonyl]phenyl]methyl]amino]-2-oxoethyl]... | [Molecular Formula]
C60H80N14O14 | [MOL File]
1341207-62-2.mol | [Molecular Weight]
1221.36 |
| Hazard Information | Back Directory | [Uses]
Pentixafor is a PET imaging agent used in the analysis of CXCR4 receptors in cancer. | [in vivo]
[68Ga]Pentixafor (15 MBq, intravenous injection, single dose) is suitable for PET imaging in the PC-3 prostate cancer xenograft model[2].
[18F]AlF-NOTA-Pentixather (0.30 MBq, intravenous injection, single dose) can target the CXCR4 receptor for specific PET imaging in the Daudi lymphoma xenograft SCID mouse model[4].
| Animal Model: | PC-3 prostate cancer xenograft (nude mouse) model[2] | | Dosage: | 15 MBq (Pentixafor labeled with 68Gallium (68Ga), [68Ga]Pentixafor) | | Administration: | Intravenous injection (i.v., injection via tail vein), single dose | | Result: | Resulted in moderate contrast in PET imaging performed in the PC-3 tumor model. |
| Animal Model: | Daudi lymphoma xenograft (SCID mouse) model[4] | | Dosage: | 0.30 MBq ([18F]AlF-NOTA-Pentixather, approx. 195 pmol/0.251 μg) | | Administration: | Intravenous injection (i.v.), single dose, imaging performed at 60 minutes post-injection | | Result: | Exhibited CXCR4-specific tumor accumulation, with low uptake in background organs. |
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| Company Name: |
InvivoChem Gold
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| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
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