| Identification | Back Directory | [Name]
1-(3-Methoxybenzyl)-3-(4-(pyridin-4-yl)thiazol-2-yl)urea | [CAS]
1342276-76-9 | [Synonyms]
PKI1313
PKI 1313
RKI-1313
RKI1313;RKI 1313
PKI1313;PKI 1313
RKI-1313 (Negative control of RKI-1447)
1-(3-Methoxybenzyl)-3-(4-(pyridin-4-yl)thiazol-2-yl)urea
Urea, N-[(3-methoxyphenyl)methyl]-N'-[4-(4-pyridinyl)-2-thiazolyl]- | [Molecular Formula]
C17H16N4O2S | [MDL Number]
MFCD27996044 | [MOL File]
1342276-76-9.mol | [Molecular Weight]
340.4 |
| Chemical Properties | Back Directory | [density ]
1.323±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 30mg/mL; DMSO: 30mg/mL; DMSO:PBS (pH 7.2) (1:1): 0.5mg/mL | [form ]
A crystalline solid | [pka]
6.38±0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
RKI-1313 is an inhibitor of Rho-associated kinase 1 (ROCK1) and 2 (IC50s = 34 and 8 μM, respectively). It has been used as a negative control for the ROCK inhibitor RKI-1447 . | [Uses]
RKI-1313 is a ROCK inhibitor with IC50s of 34, 8 μM for ROCK 1 and ROCK 2, respectively. RKI-1313 shows little effect on the phosphorylation levels of ROCK substrates, migration, invasion or anchorage-independent growth[1]. | [IC 50]
ROCK1: 34 μM (IC50); ROCK2: 8 μM (IC50) | [storage]
Store at -20°C | [References]
[1] Patel RA, et al. RKI-1447 is a potent inhibitor of the Rho-associated ROCK kinases with anti-invasive and antitumor activities in breast cancer. Cancer Res. 2012 Oct 1;72(19):5025-34. DOI:10.1158/0008-5472.CAN-12-0954 |
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