| Identification | Back Directory | [Name]
(10(11)-DiHDPA | [CAS]
1345275-22-0 | [Synonyms]
(10(11)-DiHDPA
10,11-dihydroxy-4(Z),7(Z),13(Z),16(Z),19(Z)-docosapentaenoic acid
4,7,13,16,19-Docosapentaenoic acid, 10,11-dihydroxy-, (4Z,7Z,13Z,16Z,19Z)- | [Molecular Formula]
C22H34O4 | [MOL File]
1345275-22-0.mol | [Molecular Weight]
362.5 |
| Chemical Properties | Back Directory | [Boiling point ]
537.799±50.00 °C(Press: 760.00 Torr)(predicted) | [density ]
1.035±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 50 mg/ml; DMSO: 50 mg/ml; Ethanol: 50 mg/ml; PBS (pH 7.2): 0.25 mg/ml | [pka]
4.581±0.10(predicted) |
| Hazard Information | Back Directory | [Description]
(±)10(11)-DiHDPA is produced from cytochrome P450 epoxygenase action on docosahexaenoic acid (DHA; ). It has been shown to inhibit VEGF-induced angiogenesis in mice and may have additional anti-inflammatory and anti-tumor effects.1,2 | [Uses]
(±)10(11)-DiHDPA is a fatty acid diol and a metabolite of epoxidized fatty acids (EpFAs)[1]. | [Definition]
ChEBI: 10,11-DiHDPE is a very long-chain fatty acid. | [References]
1. Zhang, G., Panigrahy, D., Mahakian, L.M., et al. Epoxy metabolites of docosahexaenoic acid (DHA) inhibit angiogenesis, tumor growth, and metastasis Proc. Natl. Acad. Sci. USA 110(16),6530-6535(2013).
2. Zhang, G., Kodani, S., and Hammock, B.D. Stabilized epoxygenated fatty acids regulate inflammation, pain, angiogenesis and cancer Prog. Lipid Res. 53,108-123(2014). |
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