| Identification | Back Directory | [Name]
Z-8-aMino-3,6-dioxaoctanoic acid | [CAS]
1345337-22-5 | [Synonyms]
16545-06-8
BocNH-PEG8-OH
NHBoc-PEG8-OH
CAS_16545-06-8
Z-NH-PEG2-CH2COOH
N-Boc-PEG8-alcohol
CBZ-NH-PEG2-CH2COOH
CBZ-NH-PEG2-acetic acid
t-boc-N-amido-PEG8-alcohol
Z-8-aMino-3,6-dioxaoctanoic acid
CBZ-8-aMino-3,6-dioxaoctanoic acid
23-(Boc-amino)-3,6,9,12,15,18,21-heptaoxa-1-tricosanol
tert-butyl(23-hydroxy-3,6,9,12,15,18,21-heptaoxatricosyl)carbamate
5,8,11,14,17,20,23-Heptaoxa-2-azapentacosanoic acid, 25-hydroxy-, 1,1-dimethylethyl ester | [Molecular Formula]
C21H43NO10 | [MDL Number]
MFCD28976659 | [MOL File]
1345337-22-5.mol | [Molecular Weight]
469.57 |
| Chemical Properties | Back Directory | [Boiling point ]
553.7±50.0 °C(Predicted) | [density ]
1.093±0.06 g/cm3(Predicted) | [form ]
Viscous Liquid | [pka]
12.23±0.46(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Description]
N-Boc-PEG8-alcohol is a PEG linker containing a hydroxyl group and Boc-protected amino group. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The Boc group can be deprotected under mild acidic conditions to form the free amine. | [Uses]
N-Boc-PEG8-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs; Alkyl/ether | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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