| Identification | Back Directory | [Name]
N-Boc-PEG9-alcohol | [CAS]
2112731-44-7 | [Synonyms]
BocNH-PEG9-OH
NHBoc-PEG9-OH
CAS_2112731-44-7
N-Boc-PEG9-alcohol
t-boc-N-amido-PEG9-alcohol
5,8,11,14,17,20,23,26-Octaoxa-2-azaoctacosanoic acid, 28-hydroxy-, 1,1-dimethylethyl ester | [Molecular Formula]
C23H47NO11 | [MDL Number]
MFCD30723250 | [MOL File]
2112731-44-7.mol | [Molecular Weight]
513.62 |
| Chemical Properties | Back Directory | [Boiling point ]
585.1±50.0 °C(Predicted) | [density ]
1.095±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C, sealed storage, away from moisture | [solubility ]
Soluble in Water, DMSO, DCM, DMF | [form ]
Liquid | [pka]
12.23±0.46(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Description]
N-Boc-PEG9-alcohol is a PEG linker containing a hydroxyl group and Boc-protected amino group. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The Boc group can be deprotected under mild acidic conditions to form the free amine. | [Uses]
N-Boc-PEG9-alcohol is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. N-Boc-PEG9-alcohol is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. | [IC 50]
Cleavable Linker; PEGs; Alkyl/ether | [References]
[1] Nello Mainolfi, wt al. Irak degraders and uses thereof. US20190192668A1. |
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