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1352416-78-4

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1352416-78-4 Structure

1352416-78-4 Structure
IdentificationBack Directory
[Name]

YCNKUIFVRZSRNL-QZTJIDSGSA-N
[CAS]

1352416-78-4
[Synonyms]

BACE1-IN-2
YCNKUIFVRZSRNL-QZTJIDSGSA-N
BACE1IN2,BACE1 IN 2,BACE-1-IN-2
2-Pyridinecarboxamide, N-[3-[(2R,3R)-5-amino-3,6-dihydro-3-methyl-2-(trifluoromethyl)-2H-1,4-oxazin-3-yl]-4-fluorophenyl]-5-cyano-
[Molecular Formula]

C19H15F4N5O2
[MDL Number]

MFCD30489294
[MOL File]

1352416-78-4.mol
[Molecular Weight]

421.35
Chemical PropertiesBack Directory
[density ]

1.47±0.1 g/cm3(Predicted)
[pka]

9.98±0.70(Predicted)
Hazard InformationBack Directory
[Uses]

BACE1-IN-2 is a 1,4-Oxazine β-Secretase 1 (BACE1) inhibitor with an IC50 of 22 nM[1].
[IC 50]

BACE1
[References]

[1] Gijsen HJM, et al. Optimization of 1,4-Oxazine β-Secretase 1 (BACE1) Inhibitors Toward a Clinical Candidate. J Med Chem. 2018 Jun 28;61(12):5292-5303. DOI:10.1021/acs.jmedchem.8b00304
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