| Identification | Back Directory | [Name]
CYM 50260 | [CAS]
1355026-60-6 | [Synonyms]
CYM 50260
2-Chloro-3-[2-(2,4-dichlorophenoxy)ethoxy]-6-(fluoromethyl)pyridine | [Molecular Formula]
C14H11Cl3FNO2 | [MOL File]
1355026-60-6.mol | [Molecular Weight]
350.6 |
| Chemical Properties | Back Directory | [Boiling point ]
469.4±45.0 °C(Predicted) | [density ]
1.407±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
<35.06mg/ml in DMSO | [form ]
Solid | [pka]
-3.50±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
CYM50260 is a potent and exquisitely selective sphingosine-1-phosphate 4 receptor (S1P4-R) agonist with an EC50 of 45 nM. CYM50260 displays no activity against S1P1-R, S1P2-R, S1P3-R and S1P5-R[1]. | [storage]
Store at -20°C | [References]
[1] Guerrero M, et al. Discovery, design and synthesis of novel potent and selective sphingosine-1-phosphate 4 receptor (S1P?-R) agonists. Bioorg Med Chem Lett. 2012 Jan 1;22(1):537-42. DOI:10.1016/j.bmcl.2011.10.096
[2] Onuma T, et al. Sphingosine 1-phosphate (S1P) suppresses the collagen-induced activation of human platelets via S1P4 receptor. Thromb Res. 2017 Aug;156:91-100. DOI:10.1016/j.thromres.2017.06.001 |
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| Company Name: |
Bide Pharmatech Ltd.
|
| Telephone: |
400-1647117 13681763483 |
| Website: |
https://www.bidepharm.com/ |
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