| Identification | Back Directory | [Name]
2,6-Pyridinedicarboxamide, N2-[(1R)-1,2-dimethylpropyl]-4-(1-methyl-1H-indol-2-yl)-N6-[2-(2-pyridinyl)ethyl]- | [CAS]
1355594-85-2 | [Synonyms]
STAT6-IN-2
2,6-Pyridinedicarboxamide, N2-[(1R)-1,2-dimethylpropyl]-4-(1-methyl-1H-indol-2-yl)-N6-[2-(2-pyridinyl)ethyl]- | [Molecular Formula]
C28H31N5O2 | [MOL File]
1355594-85-2.mol | [Molecular Weight]
469.58 |
| Chemical Properties | Back Directory | [Boiling point ]
699.6±55.0 °C(Predicted) | [density ]
1.20±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
13.25±0.46(Predicted) | [color ]
White to light yellow |
| Hazard Information | Back Directory | [Uses]
STAT6-IN-2 (Compound R-84) is a STAT6 inhibitor that can inhibit the tyrosine phosphorylation of STAT6. STAT6-IN-2 can also inhibit the secretion of eotaxin-3. STAT6-IN-2 can be used in the research of immune diseases and allergic inflammatory diseases such as asthma[1]. | [References]
[1] Zhou L, et.al. STAT6 phosphorylation inhibitors block eotaxin-3 secretion in bronchial epithelial cells. Bioorg Med Chem. 2012 Jan 15;20(2):750-8. DOI:10.1016/j.bmc.2011.12.006 |
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