| Identification | Back Directory | [Name]
Argatroban Impurity 23 | [CAS]
1356847-56-7 | [Synonyms]
[2H3]-Argatroban
Argatroban-d3 (hydrochloride)
Argatroban-d3 (Mixture Of Diastereomers) | [Molecular Formula]
C23H33D3N6O5S | [MDL Number]
MFCD09839946 | [MOL File]
1356847-56-7.mol | [Molecular Weight]
511.653 |
| Hazard Information | Back Directory | [Description]
Argatroban-d3 is intended for use as an internal standard for the quantification of argatroban by GC- or LC-MS. Argatroban is a reversible inhibitor of thrombin (IC50s = 0.01 and 0.09 μM for the free and clot-bound forms, respectively). It is selective for thrombin over factor Xa, trypsin, plasmin, and tissue plasminogen activator (Kis = 0.0045, 53, 0.19, 25.7, and 87.7 μM, respectively). It inhibits thrombin-induced platelet aggregation in washed isolated guinea pig platelets with an IC50 value of 0.077 μM. Argatroban (3.2 mg/kg, s.c.) decreases thrombus formation in a guinea pig model of iron chloride-induced arterial thrombosis. Formulations containing argatroban have been used in the prevention or treatment of thrombosis in patients with heparin-induced thrombocytopenia. | [Uses]
Labelled synthetic thrombin inhibitor. Antithrombotic. | [References]
[1] HEE DONG PARK . Antithrombotic effects of LB30870, a potent, orally active, selective and direct thrombin inhibitor, and pharmacokinetics of its prodrug[J]. Bioorganic & Medicinal Chemistry Letters, 2013, 23 17: Pages 4779-4784. DOI: 10.1016/j.bmcl.2013.07.008
[2] YASUKO KATO . Inhibition of arterial thrombosis by a protease-activated receptor 1 antagonist, FR171113, in the guinea pig[J]. European journal of pharmacology, 2003, 473 2: Pages 163-169. DOI: 10.1016/s0014-2999(03)01973-3 |
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Energy Chemical
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021-58432009 400-005-6266 |
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http://www.energy-chemical.com |
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Pharma Affiliates
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172-5066494 |
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www.chemicalbook.com/ShowSupplierProductsList694812/0_EN.htm |
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