| Identification | Back Directory | [Name]
3-Methyl-1,2,3,4-tetrahydroquinoline | [CAS]
20668-20-6 | [Synonyms]
Argatroban impurity C
Argatroban Impurity 67
Quinoline, 1,2,3,4-tetrahydro-3-me
1,2,3,4-Tetrahydro-3-methylquinoline
3-Methyl-1,2,3,4-tetrahydroquinoline
Quinoline, 1,2,3,4-tetrahydro-3-methyl- | [Molecular Formula]
C10H13N | [MDL Number]
MFCD09896588 | [MOL File]
20668-20-6.mol | [Molecular Weight]
147.22 |
| Chemical Properties | Back Directory | [Boiling point ]
117 °C(Press: 15 Torr) | [density ]
0.9931 g/cm3 | [storage temp. ]
2-8°C(protect from light) | [pka]
5.13±0.40(Predicted) | [Appearance]
Colorless to light yellow Liquid |
| Hazard Information | Back Directory | [Synthesis Reference(s)]
Chemical and Pharmaceutical Bulletin, 32, p. 2421, 1984 DOI: 10.1248/cpb.32.2421 | [Synthesis]
GENERAL STEPS: PdNPore catalyst (1.1 mg, 2 mol%) was dissolved in acetonitrile (5 mL), followed by the addition of 3-methylquinoline (7.6 mg, 0.5 mmol). The reaction system was placed on a magnetic stirrer at 50 °C for 24 h under hydrogen (5 bar) atmosphere. Upon completion of the reaction, it was purified by column chromatography (silica gel, 200-300 mesh, ethyl acetate as eluent) to afford the target product 3-methyl-1,2,3,4-tetrahydroquinoline (61.1 mg) in 83% yield. | [References]
[1] Journal of the American Chemical Society, 2011, vol. 133, # 25, p. 9878 - 9891
[2] Advanced Synthesis and Catalysis, 2017, vol. 359, # 6, p. 933 - 940
[3] Chemical Communications, 2013, vol. 49, # 63, p. 7052 - 7054
[4] Advanced Synthesis and Catalysis, 2015, vol. 357, # 16-17, p. 3529 - 3537
[5] Organic Letters, 2013, vol. 15, # 7, p. 1484 - 1487 |
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Cool Pharm, Ltd
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