| Identification | Back Directory | [Name]
Thiourea, N-[3,5-bis(trifluoromethyl)phenyl]-N'-(phenylmethyl)- | [CAS]
13571-44-3 | [Synonyms]
VPC-70063
Thiourea, N-[3,5-bis(trifluoromethyl)phenyl]-N'-(phenylmethyl)- | [Molecular Formula]
C16H12F6N2S | [MOL File]
13571-44-3.mol | [Molecular Weight]
378.34 |
| Chemical Properties | Back Directory | [Melting point ]
151-153 °C | [Boiling point ]
361.7±52.0 °C(Predicted) | [density ]
1.417±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
11.80±0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
VPC-70063 is a Myc-Max inhibitor. VPC-70067 is a close analog of the previously identified Myc inhibitor 10058-F4. VPC-70063, of a chemically different scaffold, was the best performer in a panel of in vitro assays, and the forerunner for future hit-to-lead optimization efforts. | [Uses]
VPC-70063 is a potent Myc-Max inhibitor with an IC50 value of 8.9 μM for Myc-Max transcriptional activity inhibition. VPC-70063 reduces UBE2C promotor activity and AR-V7 levels, and induces PARP cleavage. VPC-70063 induces apoptosis and blocks Myc-Max interactions with DNA. VPC-70063 can be used for researching anticancer[1]. | [References]
[1] Carabet LA, et al. Computer-aided drug discovery of Myc-Max inhibitors as potential therapeutics for prostate cancer. Eur J Med Chem. 2018 Dec 5;160:108-119. DOI:10.1016/j.ejmech.2018.09.023 |
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| Company Name: |
InvivoChem
|
| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
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