| Identification | Back Directory | [Name]
(R)-(-)-3-HYDROXYBUTYRIC ACID, SODIUM SALT | [CAS]
13613-65-5 | [Synonyms]
KTX 0101
[R]-3-Hydroxbutanoic acid
SODIUM D-3-HYDROXYBUTYRATE
SodiuM D-β-Hydroxybutyrate
Sodium (R)-3-hydroxybutyrate
sodiuM(R)-3-hydroxybutanoate
(R)-3-hydroxybutyrate sodium
D-(-)-beta-Hydroxybutyricacid
sodiuM (3R)-3-hydroxybutanoate
(R)-(-)-SODIUM- 3-HYDROXYBUTYRATE
(R)-3-Hydroxybutanoic acid sodium
Sodium -3-Hydroxybutyrate-2,4-13C2
(R)-(-)-3-HydroxyButyric Acid Sodium
(R)-3-HYDROXYBUTYRIC ACID SODIUM SALT
[R]-3-HYDROXBUTANOIC ACID SODIUM SALT
(R)-3-Hydroxybutyric Acid,Sadium Salt
(3R)-3-Hydroxybutanoic Acid SodiuM Salt
(R)-3-Hydroxybutanoic Acid Sodium Salt
(R)-(-)-3-HYDROXYBUTYRIC ACID, SODIUM SA
(R)-(-)-3-Hydroxybutyric acid sodium saL
D-(-)-BETA-HYDROXYBUTYRIC ACID SODIUM SALT
(R)-3-Hydroxybutanoic Acid MonosodiuM Salt
(R)-(-)-3-HYDROXYBUTYRIC ACID, SODIUM SALT
D-(-)-3-Hydroxybutyric Acid MonosodiuM Salt
(R)-()-3-Hydroxyisobutyric acid Sodium salt
Natural (R)-3-Hydroxybutanoic Acid Sodium Salt
(R)-(-)-3-HYDROXYBUTYRIC ACID, SODIUM SALT Basic information
(R)-(-)-3-Hydroxybutyric acid sodiuM salt optical purity ee: 99% (GLC) | [EINECS(EC#)]
203-536-5 | [Molecular Formula]
C4H7NaO3 | [MDL Number]
MFCD00077788 | [MOL File]
13613-65-5.mol | [Molecular Weight]
126.09 |
| Chemical Properties | Back Directory | [Melting point ]
149-155 °C(lit.)
| [storage temp. ]
2-8°C
| [solubility ]
DMSO (Slightly), Water (Slightly) | [form ]
Solid | [color ]
White to Off-White | [Optical Rotation]
[α]22/D 14°, c = 10 in H2O | [Water Solubility ]
Water: 100 mg/mL (793.08 mM) | [BRN ]
6118796 | [Stability:]
Hygroscopic | [Cosmetics Ingredients Functions]
ANTI-SEBUM
SKIN CONDITIONING - HUMECTANT
PLASTICISER
SKIN CONDITIONING - MISCELLANEOUS | [InChI]
InChI=1/C4H8O3.Na.H/c1-3(5)2-4(6)7;;/h3,5H,2H2,1H3,(H,6,7);;/t3-;;/s3 | [InChIKey]
DIKSWKJUJFMKBT-LPWWCTNINA-N | [SMILES]
C(C(=O)O)[C@H](O)C.[NaH] |&1:4,r| |
| Hazard Information | Back Directory | [Chemical Properties]
mp 165-167°C | [Uses]
chiral synthon | [Uses]
Optically active 3-hydroxybutyric acids are key intermediates of the biosynthesis and metabolism of fatty acids and exist widely in biological systems. | [Synthesis]
In a 500 mL three-necked flask, methyl (R)-3-hydroxybutyrate (76.0 g) made from Example 1 was added, followed by 300 mL of water. The reaction temperature was controlled to be below 30 °C, and sodium hydroxide (25.8 g) was added slowly in batches over a period of 3 hours. After addition, maintain the temperature no higher than 10°C and continue to stir the reaction for 3 hours until the reaction is complete. Add 0.3 g of activated carbon and filter after continuous stirring for 0.5 hours. The filtrate was concentrated to 100 mL, at which time a large amount of solid precipitated. Crystallization was stirred at room temperature for 1 hour, centrifuged and dried in vacuum to obtain 68.9 g of (R)-(-)-3-hydroxybutyric acid sodium salt as a white solid with a yield of 85.0% and an ee value of 91.5%. | [References]
[1] Patent: CN107162893, 2017, A. Location in patent: Paragraph 0042; 0043 |
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