| Identification | More | [Name]
Salinomycin | [CAS]
53003-10-4 | [Synonyms]
SALINOMYCIN
SALINOMYCIN SODIUM
SALINOMYCIN SODIUM SALT
coxistac
SALINOMYCIN GRANULE
Salinomycin Premix 12%
SALINOMYCIN FROM STREPTOMYCES ALBUS
SALINOMYCIN 90%
SV sodium salt,2,5 salinomycin hydrate
(2R)-2-((5S)-6-{5-[(10S,12R)-2-((6S,5R)-5-Ethyl-5-hydroxy-6-methylperhydro-2H-pyran-2-yl)-15-hydroxy-2,10,12-trimethyl-1,6,8-trioxadispiro[4.1.5.3]pentadec-13-en-9-yl](1S,2S,3S,5R)-2-hydroxy-1,3-dimethyl-4-oxoheptyl}-5-methylperhydro-2H-pyran-2-yl)butanoic acid
Salinomycin
Antibiotic-61477 | [EINECS(EC#)]
258-290-1 | [Molecular Formula]
C42H69NaO11 | [MDL Number]
MFCD00036900 | [Molecular Weight]
772.98 | [MOL File]
53003-10-4.mol |
| Chemical Properties | Back Directory | [Appearance]
solid | [Melting point ]
112.5-113.5 °C(lit.) | [alpha ]
D25 -63° (c = 1 in ethanol) | [Boiling point ]
839.2±65.0 °C(Predicted) | [density ]
1.18±0.1 g/cm3(Predicted) | [Fp ]
>110°(230°F) | [storage temp. ]
2-8°C
| [solubility ]
insoluble in H2O; ≥142.2 mg/mL in EtOH; ≥91.8 mg/mL in DMSO | [form ]
White solid | [pka]
6.4 (DMF) | [color ]
White to light yellow | [Stability:]
Stable, but may be heat sensitive-keep cool. Incompatible with strong oxidizing agents. | [biological source]
Streptomyces albus | [Optical Rotation]
-6325 (cl, ethanol) | [Water Solubility ]
Soluble in methanol. Insoluble in water | [Merck ]
13,8415 | [InChIKey]
KQXDHUJYNAXLNZ-XQSDOZFQSA-N | [LogP]
5.596 (est) | [CAS DataBase Reference]
53003-10-4(CAS DataBase Reference) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS06 | [Signal word ]
Danger | [Hazard statements ]
H300 | [Precautionary statements ]
P264-P270-P301+P310-P405-P501 | [Hazard Codes ]
T,Xi | [Risk Statements ]
R25:Toxic if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S36:Wear suitable protective clothing .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . | [RIDADR ]
UN 3462 6.1/PG 2
| [WGK Germany ]
3
| [RTECS ]
VO8620000
| [F ]
10 | [HazardClass ]
6.1(a) | [PackingGroup ]
II | [Storage Class]
6.1A - Combustible acute toxic Cat. 1 and 2
very toxic hazardous materials | [Hazard Classifications]
Acute Tox. 2 Oral | [Hazardous Substances Data]
53003-10-4(Hazardous Substances Data) | [Toxicity]
LD50 in mice (mg/kg): 18 i.p.; 50 orally (Miyazaki) |
| Material Safety Data Sheet(MSDS) | Back Directory | [msds information]
(2R)-2-((5S)-6-{5-[(10S,12R)-2-((6S,5R)-5-Ethyl-5-hydroxy-6-methylperhydro-2H-pyran-2-yl)-15-hydroxy-2,10,12-trimethyl-1,6,8-trioxadispiro[4.1.5.3]pentadec-13-en-9-yl](1S,2S,3S,5R)-2-hydroxy-1,3-dimethyl-4-oxoheptyl}-5-methylperhydro-2H-pyran-2-yl)butanoic acid(53003-10-4).msds |
| Hazard Information | Back Directory | [Description]
Salinomycin was found in the culture mycelium of Streptomyces albus by Otake et al. of the University of Tokyo in 1973. Like other polyether ionophore antibiotics, it shows activity against gram-positive bacteria, fungi, and Coccidium. Salinomycin has been used as a feed additive to protect poultry against coccidial infections. | [Chemical Properties]
solid | [Uses]
Salinomycin was used as a standard in the development of LC-MS/MS method for detection of residual coccidiostats in egg and muscle samples. It was used to screen out CD44+CD24- mesenchymal-like subpopulation within breast carcinomas. | [Uses]
antibacterial | [Uses]
Salinomycin is a polyether ionophore with broad spectrum Gram positive and anti-coccidial activity. Salinomycin has a high affinity for monovalent cations, particularly potassium. Salinomycin is used to control coccidia in animals and for growth promotion in ruminants. Recently, salinomycin has been shown to inhibit cancer stem cells and is >100 times more potent than taxol. While the mechanism of action is unknown, it was noted that among the 60,000 compounds screened, another monovalent ionophore, nigericin, and a chloride channel inhibitor, avermectin, were also active. | [Definition]
ChEBI: Salinomycin is a polyketide and a spiroketal. It has a role as an animal growth promotant and a potassium ionophore. | [General Description]
Chemical structure: polyether | [Biological Activity]
salinomycin (sal), which is a polyether ionophore antibiotic from streptomyces albus, has been proven to be able to kill different types of human cancer cells, most likely via interfering with abc drug transporters, the wnt/β-catenin signaling pathway, or other pathways. | [Biochem/physiol Actions]
Salinomycin produced by Streptomyces albus is a carboxylic polyether ionophore with antibiotic and anti-cancer properties. It induces cell death in some types of cancer cells such as breast, lung, gastric cancer, leukemia and osteosarcoma. Salinomycin inhibits multidrug resistance protein 1 and induces apoptosis by the generation of reactive oxygen species that cause DNA damage and inactivation of Stat3. Use of salinomycin as antibiotic results in lowered spermatozoa count and motility and decreased steroidogenesis in mice. | [in vitro]
several hepatocellular carcinoma (hcc) cell lines were treated with sal. results showed that sal inhibited proliferation and decreased pcna levels. cell cycle analysis showed that sal caused cell cycle arrest in different phases. sal induced apoptosis as characterized by an increase in the bax/bcl-2 ratio. compared to control, β-catenin expression was down-regulated by sal treatment significantly. the ca2+ concentration in hcc cells was examined by flow cytometry and it was found that higher ca2+ concentrations were observed in sal treatment groups [1]. | [in vivo]
the in vivo anti-tumor effect of sal was verified using the hepatoma orthotopic tumor model and results showed that the liver tumor size in sal-treated groups decreased. immunohistochemistry and tunel staining also demonstrated that sal could in vivo inhibit proliferation and induced apoptosis [1]. | [IC 50]
7.7, 13.7 and 10.4 μm for hepg2, smmc-7721 and bel-7402 cell line, respectively (after 24h treatment) | [References]
[1] wang f,he l,dai wq,xu yp,wu d,lin cl,wu sm,cheng p,zhang y,shen m,wang cf,lu j,zhou yq,xu xf,xu l,guo cy. salinomycin inhibits proliferation and induces apoptosis of human hepatocellular carcinoma cells in vitro and in vivo. plos one.2012;7(12):e50638. |
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NCE Biomedical Co.,Ltd.
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Simagchem Corp.
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www.simagchem.com |
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