| Identification | Back Directory | [Name]
Benzeneacetamide, N-[5-(2-chlorobenzoyl)-4-(3-chlorophenyl)-2-thiazolyl]-4-(ethylsulfonyl)- | [CAS]
1361413-10-6 | [Synonyms]
RORModulatorI
ROR-Modulator-I
ROR Modulator I
Benzeneacetamide, N-[5-(2-chlorobenzoyl)-4-(3-chlorophenyl)-2-thiazolyl]-4-(ethylsulfonyl)- | [Molecular Formula]
C26H20Cl2N2O4S2 | [MOL File]
1361413-10-6.mol | [Molecular Weight]
559.48 |
| Hazard Information | Back Directory | [Description]
GUN13106, also known as ROR Modulator I, is the first potent inverse agonist of retinoid-related orphan receptor (ROR) with dual selectivity for RORβ and RORγt. This product has no formal name at the moment. | [Uses]
RORγt inhibitor 3 is an orally active and potent retinoic acid receptor-related orphan receptor-gamma-t (RORγt) inhibitor. RORγt inhibitor 3 shows high binding affinity and inhibitory activity of Th17 cell differentiation. RORγt inhibitor 3 also shows efficacy in both mouse experimental autoimmune encephalomyelitis (EAE) and collagen induced arthritis (CIA) models[1]. | [References]
[1] Wang Y, et al. Discovery of novel N-(5-(arylcarbonyl)thiazol-2-yl)amides and N-(5-(arylcarbonyl)thiophen-2-yl)amides as potent RORγt inhibitors. Bioorg Med Chem. 2014 Jan 15;22(2):692-702. DOI:10.1016/j.bmc.2013.12.021 |
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