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1363281-27-9

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1363281-27-9 Structure

1363281-27-9 Structure
IdentificationBack Directory
[Name]

VU 0409551
[CAS]

1363281-27-9
[Synonyms]

VU 0409551
JNJ-46778212
[6,7-Dihydro-2-(phenoxymethyl)oxazolo[5,4-c]pyridin-5(4H)-yl](fluorophenyl)methanone
(4-fluorophenyl)-[2-(phenoxymethyl)-6,7-dihydro-4H-oxazolo[5,4-c]pyridin-5-yl]methanone
Methanone, [6,7-dihydro-2-(phenoxymethyl)oxazolo[5,4-c]pyridin-5(4H)-yl](4-fluorophenyl)-
[Molecular Formula]

C20H17FN2O3
[MOL File]

1363281-27-9.mol
[Molecular Weight]

352.36
Chemical PropertiesBack Directory
[Boiling point ]

545.8±50.0 °C(Predicted)
[density ]

1.308±0.06 g/cm3(Predicted)
[storage temp. ]

Sealed in dry,2-8°C
[solubility ]

DMSO: soluble; Ethanol: soluble
[form ]

A crystalline solid
[pka]

1.35±0.20(Predicted)
[color ]

Light yellow to yellow
[InChIKey]

QUZLMKNNIUSREV-UHFFFAOYSA-N
[SMILES]

O=C(N1CCC2=C(C1)OC(COC3=CC=CC=C3)=N2)C4=CC=C(C=C4)F
Safety DataBack Directory
[WGK Germany ]

WGK 3
[Storage Class]

11 - Combustible Solids
Hazard InformationBack Directory
[Uses]

VU 0409551 is an mGlu5 allosteric modulator.
[Biological Activity]

VU0409551 (JNJ-46778212) is an orally availablepotent and selective biased metabotropic glutamate receptor subtype 5 positive allosteric modulator (mGlu5 PAM). VU0409551 (JNJ-46778212) selectively potentiates mGlu5 coupling to Gaq-mediated signaling without modulation of NMDAR currents in hippocampal neurons. VU0409551 exhibits potent antipsychotic-like and cognition enhancing activity in animal models.
[in vivo]

In oral brain/plasma studies, JNJ-46778212 displays excellent CNS penetration[1]. JNJ-46778212 enhances NMDAR function and rescues long-term potentiation in hippocampal slices obtained from SR?/? mice. The administration of JNJ-46778212 to SR?/? mice reverses their deficits in several neuroplasticity signaling pathways and improves their contextual fear memory[2].

[IC 50]

mGlu5 Receptor: 260 nM (EC50)
[storage]

Store at -20°C
Spectrum DetailBack Directory
[Spectrum Detail]

VU 0409551(1363281-27-9)1HNMR
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