1363281-27-9
中文名称
1363281-27-9
英文名称
VU 0409551
CAS
1363281-27-9
分子式
C20H17FN2O3
分子量
352.36
MOL 文件
1363281-27-9.mol
更新日期
2025/05/09 07:04:53
1363281-27-9 结构式
基本信息
中文别名
化合物 T15619(4-氟苯基)(2-(苯氧基甲基)-6,7-二氢恶唑并[5,4-C]吡啶-5(4H)-基)甲酮
英文别名
VU 0409551JNJ-46778212
[6,7-Dihydro-2-(phenoxymethyl)oxazolo[5,4-c]pyridin-5(4H)-yl](fluorophenyl)methanone
(4-fluorophenyl)-[2-(phenoxymethyl)-6,7-dihydro-4H-oxazolo[5,4-c]pyridin-5-yl]methanone
Methanone, [6,7-dihydro-2-(phenoxymethyl)oxazolo[5,4-c]pyridin-5(4H)-yl](4-fluorophenyl)-
物理化学性质
沸点545.8±50.0 °C(Predicted)
密度1.308±0.06 g/cm3(Predicted)
储存条件2-8°C
储存条件Sealed in dry,2-8°C
溶解度DMSO: soluble; Ethanol: soluble
酸度系数(pKa)1.35±0.20(Predicted)
形态结晶固体
颜色Light yellow to yellow
1363281-27-9价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2025/02/08 | HY-19559 | 1363281-27-9 JNJ-46778212 | 1363281-27-9 | 5 mg | 700元 |
| 2025/02/08 | HY-19559 | 1363281-27-9 JNJ-46778212 | 1363281-27-9 | 10mM * 1mLin DMSO | 770元 |
| 2025/02/08 | HY-19559 | 1363281-27-9 JNJ-46778212 | 1363281-27-9 | 10mg | 1200元 |
常见问题列表
生物活性
JNJ-46778212 (VU 0409551) 是 mGlu5 正变构调节剂，EC50 值为260 nM。靶点
|
mGlu5 Receptor 260 nM (EC 50 ) |
体内研究
In oral brain/plasma studies, JNJ-46778212 displays excellent CNS penetration. JNJ-46778212 enhances NMDAR function and rescues long-term potentiation in hippocampal slices obtained from SR −/− mice. The administration of JNJ-46778212 to SR −/− mice reverses their deficits in several neuroplasticity signaling pathways and improves their contextual fear memory.