| Identification | Back Directory | [Name]
WS DBCO-Biotin | [CAS]
1363444-70-5 | [Synonyms]
WS DBCO-Biotin
DBCO-Sulfo-link-biotin,WS DBCO-Biotin
2-Propanesulfonic acid, 1-[[3-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-3-oxopropyl]amino]-3-[[5-[(3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-1-oxopentyl]amino]-1-oxo- | [Molecular Formula]
C31H35N5O7S2 | [MDL Number]
MFCD28122948 | [MOL File]
1363444-70-5.mol | [Molecular Weight]
653.77 |
| Hazard Information | Back Directory | [Description]
DBCO-Sulfo-Link-biotin is an anqueous soluble biotin reagent for introducing a biotin moiety to proteins and cell surfaces containing azide moiety through copper-free Click Chemistry. This biotin reagent is membrane-impermeable due to its negatively charged, water soluble sulfonate group. DBCO is commonly used for copper-free Click Chemistry reactions. | [Uses]
DBCO-Sulfo-Link-biotin is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. DBCO-Sulfo-Link-biotin is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. | [IC 50]
Cleavable Linker | [References]
[1] Portnoff AD, et al. An antidote approach to reduce risk and broaden utility of antibody-based therapeutics. J Biol Chem. 2017 May 19;292(20):8498-8506. |
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