| Identification | Back Directory | [Name]
Banoxantrone dihydrochloride | [CAS]
136470-65-0 | [Synonyms]
Banoxantrone
YZBAXVICWUUHGG-UHFFFAOYSA-N
Banoxantrone dihydrochloride
9,10-Anthracenedione, 1,4-bis[[2-(dimethyloxidoamino)ethyl]amino]-5,8-dihydroxy-
1,4-Bis{[2-(dimethylamino)ethyl]amino}-5,8-dihydroxyanthracene-9,10-dione bis-N-oxide | [Molecular Formula]
C22H28N4O6 | [MOL File]
136470-65-0.mol | [Molecular Weight]
444.48 |
| Hazard Information | Back Directory | [Uses]
Banoxantrone (AQ4N) is a hypoxia-activated prodrug of topoisomerase II inhibitor AQ4 (Bioreductive AQ4 precursor). studies have shown that its has also exhibited anti-tumor efficacy in vivo when combined with oxic cell cytotoxins. | [in vivo]
Banoxantrone (200 mg/kg; i.p.; single dose) significantly inhibits T50/80 tumours and induces cell damage in BDF mice[1]. | [IC 50]
iNOS |
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