| Identification | More | [Name]
SNAP | [CAS]
67776-06-1 | [Synonyms]
SUP
SNAP
SNP25
Super protein
N-Acetyl-S-nitrosopenicillamine
Valine,N-acetyl-3-(nitrosothio)-
N-(ACETYLOXY)-3-NITROSOTHIOVALINE
N-Acetyl-3-(nitrosothio)-DL-valine
S-NITROSO-N-ACETYL-D,L-PENICILLAMINE
(+/-)-S-NITROSO-N-ACETYLPENICILLAMINE
SNAP [S-Nitroso-N-acetylpenicillaMine]
S-Nitroso-N-acetyl-DL-penicillamine,98%
2-acetamido-3-methyl-3-(nitrosothio)butanoic acid
2-acetamido-3-methyl-3-(nitrososulfanyl)butaic acid
Anti-SNAP25, C-Terminal antibody produced in rabbit
(R)-2-acetaMido-3-Methyl-3-(nitrosothio)butanoic acid
(2R)-2-(acetylamino)-3-methyl-3-(nitrososulfanyl)butanoate
2-acetamido-3-methyl-3-(nitrososulfanyl)butanoic acid USP/EP/BP
N-Acetyl-3-(nitrosothio)-DL-valine, S-Nitroso-N-acetylpenicillamine, SNAP
S-Nitroso-N-acetyl-DL-penicillamine,N-Acetyl-3-(nitrosothio)-DL-valine, S-Nitroso-N-acetylpenicillamine, SNAP | [Molecular Formula]
C7H12N2O4S | [MDL Number]
MFCD00272624 | [Molecular Weight]
220.25 | [MOL File]
67776-06-1.mol |
| Chemical Properties | Back Directory | [Appearance]
green crystalline solid | [Melting point ]
150.5°C | [density ]
1.4261 (rough estimate) | [refractive index ]
1.5400 (estimate) | [RTECS ]
YV9383000 | [storage temp. ]
−20°C
| [solubility ]
H2O: ≥2 mg/mL
| [form ]
powder
| [pka]
3.06±0.10(Predicted) | [color ]
green
| [Water Solubility ]
H2O: ≥2mg/mL
DMSO: ≥20mg/mL, clear (faint green to very dark green) | [InChI]
1S/C7H12N2O4S/c1-4(10)8-5(6(11)12)7(2,3)14-9-13/h5H,1-3H3,(H,8,10)(H,11,12) | [InChIKey]
ZIIQCSMRQKCOCT-UHFFFAOYSA-N | [SMILES]
CC(=O)NC(C(O)=O)C(C)(C)SN=O | [CAS DataBase Reference]
67776-06-1(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| Hazard Information | Back Directory | [Description]
SNAP is an S-nitrosothiol which serves as a NO donor and a potent vasodilator. Its stability in solution varies from seconds to hours depending on temperature, buffer composition and metal content.1,2,3,4 At pH 6-8 and 37°C, the half-life of SNAP is approximately six hours in the presence of transition metal ion chelators.5,4 | [Chemical Properties]
2-acetamido-3-methyl-3-(nitrososulfanyl)butanoic acid is green crystalline solid
| [Uses]
Produced concentration-related relaxations of mouse anococcygeus, in a range similar to that already found for NO and other nitrovasodilators. A potent relaxant of non-vascular smooth muscle. Serves as an NO donor. | [Biochem/physiol Actions]
NO donor; vasodilator, smooth muscle relaxant, lymphocyte activator. Activates soluble guanylyl cyclase. | [in vivo]
SNAP (100μM, 300μM) causes small but significant increases of the electrically evoked [3H]-acetylcholine release in guinea-pig tracheal[4].
| [storage]
Store at -20°C,unstable in solution, ready to use. | [References]
[1] BEATRICE ROY Marc F A du Moulinet d’Hardemare. New Thionitrites: Synthesis, Stability, and Nitric Oxide Generation[J]. The Journal of Organic Chemistry, 1994, 59 23: 7019-7026. DOI: 10.1021/jo00102a028
[2] R J SINGH. Mechanism of nitric oxide release from S-nitrosothiols.[J]. The Journal of Biological Chemistry, 1996, 271 31: 18596-18603. DOI: 10.1074/jbc.271.31.18596 |
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Sigma-Aldrich
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