| Identification | Back Directory | [Name]
DHODH-IN-15 | [CAS]
1364791-88-7 | [Synonyms]
DHODH-IN-15
DHODH IN 15,DHODHIN15
1,2,5-Oxadiazole-3-carboxamide, N-[1,1'-biphenyl]-4-yl-4,5-dihydro-4-oxo- | [Molecular Formula]
C15H11N3O3 | [MDL Number]
MFCD34469938 | [MOL File]
1364791-88-7.mol | [Molecular Weight]
281.27 |
| Hazard Information | Back Directory | [Uses]
DHODH-IN-15 (Compound 7b) is a hydroxyfurazan analog of A771726. DHODH-IN-15 is a dihydroorotate dehydrogenase (DHODH) inhibitor with an IC50 of 11 μM for rat liver DHODH. DHODH-IN-15 can be used for rheumatoid arthritis[1]. | [References]
[1] Lolli ML, et al. New inhibitors of dihydroorotate dehydrogenase (DHODH) based on the 4-hydroxy-1,2,5-oxadiazol-3-yl (hydroxyfurazanyl) scaffold. Eur J Med Chem. 2012 Mar;49:102-9. DOI:10.1016/j.ejmech.2011.12.038 |
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