| Identification | Back Directory | [Name]
4-Thiazolidinone, 5-[[4-[3-(dimethylamino)propoxy]phenyl]methylene]-3-ethyl-2-thioxo- | [CAS]
1367579-04-1 | [Synonyms]
Rhodadyn C10, cell-permeable dynamin I inhibitor
4-Thiazolidinone, 5-[[4-[3-(dimethylamino)propoxy]phenyl]methylene]-3-ethyl-2-thioxo- | [Molecular Formula]
C17H22N2O2S2 | [MOL File]
1367579-04-1.mol | [Molecular Weight]
350.5 |
| Chemical Properties | Back Directory | [Melting point ]
92-94 °C | [Boiling point ]
490.7±55.0 °C(predicted) | [density ]
1.25±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [pka]
9.30±0.28(predicted) |
| Hazard Information | Back Directory | [Uses]
Rhodady C10 (Compound C10) is a dynamin I GTPase inhibitor. Rhodady C10 blocks receptor-mediated endocytosis (IC50: 7 μM). Dynamin is involved in clathrin-independent endocytosis, phagocytosis, and caveolae internalization[1]. | [References]
[1] Robertson MJ, et al. The Rhodadyns, a New Class of Small Molecule Inhibitors of Dynamin GTPase Activity. ACS Med Chem Lett. 2012 Mar 26;3(5):352-6. DOI:10.1021/ml200284s |
|
| Company Name: |
Abcam Limited
|
| Tel: |
021-2070050 400921018 |
| Website: |
www.abcam.cn |
|