| Identification | Back Directory | [Name]
5H-Pyrido[4,3-b]carbazole-5,11(6H)-dione | [CAS]
73326-98-4 | [Synonyms]
5H-Pyrido[4,3-b]carbazole-5,11(6H)-dione | [Molecular Formula]
C15H8N2O2 | [MDL Number]
MFCD28953033 | [MOL File]
73326-98-4.mol | [Molecular Weight]
248.24 |
| Chemical Properties | Back Directory | [Melting point ]
>300 °C(Solv: ethyl ether (60-29-7); hexane (110-54-3)) | [Boiling point ]
543.0±40.0 °C(Predicted) | [density ]
1.506±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
11.81±0.20(Predicted) | [color ]
Light brown to brown |
| Hazard Information | Back Directory | [Description]
Ellipticine quinone, also known as NSC-383230, is a Drp1 inhibitor. rpitor1 and Drpitor1a inhibited the GTPase activity of Drp1 without inhibiting the GTPase of dynamin 1. Ellipticine quinone showed greater potency than the current std. Drp1 GTPase inhibitor, mdivi-?1, (IC50 for mitochondrial fragmentation are (0.06, and 10 μM, resp.)?. Ellipticine quinone suppressed lung cancer tumor growth in a mouse xenograft model. Ellipticine quinone also inhibited mitochondrial ROS prodn., prevented mitochondrial fission, and improved right ventricular diastolic dysfunction during IR injury. | [Uses]
Drpitor1a is a potent Drp1 inhibitor. Drpitor1a inhibits mitochondrial ROS production, preventes mitochondrial fission, and improves right ventricular diastolic dysfunction during IR (ischemia reperfusion) injury. Drpitor1a has the potential for the research of lung cancer[1][2]. | [References]
[1] Wu D, et al. Identification of novel dynamin-related protein 1 (Drp1) GTPase inhibitors: Therapeutic potential of Drpitor1 and Drpitor1a in cancer and cardiac ischemia-reperfusion injury. FASEB J. 2020 Jan;34(1):1447-1464. DOI:10.1096/fj.201901467R
[2] Wu D, et al. Efficacy of Drpitor1a, a Dynamin-Related Protein 1 inhibitor, in Pulmonary Arterial Hypertension. bioRxiv [Preprint]. 2023 Dec 23:2023.12.21.572836. DOI:10.1101/2023.12.21.572836 |
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