| Identification | Back Directory | [Name]
1-Dehydro-10-gingerdione | [CAS]
136826-50-1 | [Synonyms]
1-Dehydro-10-gingerdione
1-(4-Hydroxy-3-methoxyphenyl)-1-tetradecene-3,5-dione
1-Tetradecene-3,5-dione, 1-(4-hydroxy-3-methoxyphenyl)- | [Molecular Formula]
C21H30O4 | [MOL File]
136826-50-1.mol | [Molecular Weight]
346.46 |
| Chemical Properties | Back Directory | [Boiling point ]
495.2±40.0 °C(Predicted) | [density ]
1.054±0.06 g/cm3(Predicted) | [solubility ]
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | [form ]
Powder | [pka]
9.02±0.46(Predicted) |
| Hazard Information | Back Directory | [Uses]
1-Dehydro-[10]-gingerdione directly inhibits IKKβ activity by targeting the activation loop of IKKβ, thus disrupting IKKβ-catalysed IκBα phosphorylation in macrophages stimulated with agonists. 1-Dehydro-[10]-gingerdione inhibits LPS (HY-D1056)-induced NF-κB transcriptional activity. 1-Dehydro-[10]-gingerdione has?the?potential?for?NF-κB-associated inflammation and autoimmune disorders research[1]. | [target]
NF-kB | TLR | IkB | TNF-α | NOS | COX | IL Receptor | AP-1 | IFN-γ | IKK | [References]
[1] Hwa Young Lee, et al. 1-Dehydro-[10]-gingerdione from ginger inhibits IKKβ activity for NF-κB activation and suppresses NF-κB-regulated expression of inflammatory genes. Br J Pharmacol. 2012 Sep;167(1):128-40. DOI:10.1111/j.1476-5381.2012.01980.x |
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