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136959-96-1

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136959-96-1 Structure

136959-96-1 Structure
IdentificationBack Directory
[Name]

RU 43044
[CAS]

136959-96-1
[Synonyms]

RU044
RU-044
RU 43044
Androsta-4,9(11)-dien-3-one, 17-hydroxy-19-(4-methylphenyl)-17-(1-propynyl)-, (17β)-
[Molecular Formula]

C29H34O2
[MOL File]

136959-96-1.mol
[Molecular Weight]

414.59
Chemical PropertiesBack Directory
[Boiling point ]

584.8±50.0 °C(Predicted)
[density ]

1.16±0.1 g/cm3(Predicted)
[pka]

12.90±0.60(Predicted)
Hazard InformationBack Directory
[Uses]

RU 43044 is a glucocorticoid receptor antagonist. RU 43044 shows an antidepressant-like effect, probably via an inhibition of enhanced prefrontal dopaminergic neurotransmission in these mouse models[1].
[References]

[1] Ago Y, et al. Antidepressant-like effects of the glucocorticoid receptor antagonist RU-43044 are associated with changes in prefrontal dopamine in mouse models of depression. Neuropharmacology. 2008 Dec;55(8):1355-63. DOI:10.1016/j.neuropharm.2008.08.026
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