| Identification | Back Directory | [Name]
CA-5f | [CAS]
1370032-19-1 | [Synonyms]
CA-5f
CA-5F;CA 5F;CA5F;1370032-19-1
-5-(1H-indol-3-ylmethylene)-1-methyl-, (3E,5E)-
4-Piperidinone, 3-[(3,4-dimethoxyphenyl)methylene]-5-(1H-indol-3-ylmethylene)-1-methyl-, (3E,5E)- | [Molecular Formula]
C24H24N2O3 | [MOL File]
1370032-19-1.mol | [Molecular Weight]
388.46 |
| Chemical Properties | Back Directory | [Boiling point ]
639.7±55.0 °C(Predicted) | [density ]
1.253±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 77.5 mg/mL (199.51 mM);Water : < 0.1 mg/mL (insoluble) | [form ]
Solid | [pka]
16.06±0.30(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
CA-5f is a potent late-stage macroautophagy/autophagy inhibitor via inhibiting autophagosome-lysosome fusion. CA-5f increases LC3B-II (a marker to monitor autophagy) and SQSTM1 protein, and also increases ROS production. Anti-tumor activity[1]. | [Biological Activity]
CA-5f is a potent late macroautophagy/autophagy inhibitor, acting by inhibiting autophagosome-lysosome fusion. It increases LC3B-II (a marker that monitors autophagy) and SQSTM1 protein levels and promotes ROS production. Has antitumor activity. | [in vivo]
CA-5f (40 mg/kg, ip, every 2 days for up to 30 days) is well tolerated, and potently inhibits the growth of tumor in nude mice bearing A549 lung cancer cells.
CA-5f (40 mg/kg, ip) suppresses autophagic flux and induces apoptosis in nude mice bearing A549 lung cancer cells.
| Animal Model: | < td class="col2"> Nude mice bearing A549 lung cancer cells | Dosage: | 40 mg /kg | | Administration: | Injected via caudal vein, every 2 days for up to 30 days < /td> | | Result: | Significantly suppressed tumor volume and weight in mice, increased the number of apoptotic cells in mice . | | [target]
| [storage]
Store at -20°C | [References]
[1] Zhang L, et al. Identification of compound CA-5f as a novel late-stage autophagy inhibitor with potent anti-tumor effect against non-small cell lung cancer. Autophagy. 2019 Mar;15(3):391-406. DOI:10.1080/15548627.2018.1511503 |
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| Company Name: |
BOC Sciences
|
| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
| Company Name: |
Giant chemicals
|
| Tel: |
028-85434334 18108076537 |
| Website: |
http://www.gianthx.com |
|