| Identification | Back Directory | [Name]
4-(4-(1-isopropyl-7-oxo-1,4,6,7-tetrahydrospiro[indazole-5,4'-piperidine]-1'-carbonyl)-6-methoxypyridin-2-yl)benzoicacid | [CAS]
1370448-25-1 | [Synonyms]
EOS-62091
PF-05221304
Clesacostat
STAT5 Inhibitor III
PF-05221304(Clesacostat)
4-(4-(1-isopropyl-7-oxo-1,4,6,7-tetrahydrospiro[indazole-5,4'-piperidine]-1'-carbonyl)-6-methoxypyridin-2-yl)benzoicacid
Benzoic acid, 4-[6-methoxy-4-[[1,4,6,7-tetrahydro-1-(1-methylethyl)-7-oxospiro[5H-indazole-5,4'-piperidin]-1'-yl]carbonyl]-2-pyridinyl]- | [Molecular Formula]
C28H30N4O5 | [MDL Number]
MFCD33023235 | [MOL File]
1370448-25-1.mol | [Molecular Weight]
502.56 |
| Chemical Properties | Back Directory | [Boiling point ]
745.3±60.0 °C(Predicted) | [density ]
1.36±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 100 mg/mL (198.98 mM);Ethanol: 5 mg/mL (9.95 mM) | [pka]
3.93±0.10(Predicted) | [Water Solubility ]
Water: Insoluble | [InChIKey]
LXZMHBHEXAELHH-UHFFFAOYSA-N | [SMILES]
C(O)(=O)C1=CC=C(C2=NC(OC)=CC(C(N3CCC4(CC3)CC(=O)C3=C(C4)C=NN3C(C)C)=O)=C2)C=C1 |
| Hazard Information | Back Directory | [Description]
PF-05221304 is an inhibitor of acetyl-CoA carboxylase 1 (ACC1) and ACC2 (IC50s = 12.4 and 8.7 nM, respectively).1 It inhibits de novo lipid synthesis (IC50 = 61 nM) and increases fatty acid oxidation in primary human hepatocytes. PF-05221304 reduces the accumulation of triglycerides composed of de novo-derived fatty acids but not dietary essential fatty acids in primary human hepatocytes. In vivo, PF-05221304 (10 and 100 mg/kg) reduces hepatic malonyl-CoA production and de novo lipogenesis in rats. It reduces hepatic fibrosis, alanine transaminase (ALT) and aspartate aminotransferase (AST) levels, and triglyceride accumulation in a rat model of non-alcoholic steatohepatitis (NASH) induced by a choline-deficient and high-fat diet (CDAHFD).WARNING This product is not for human or veterinary use. | [storage]
Store at -20°C |
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