| Identification | Back Directory | [Name]
3,4-Pyrrolidinediol, 2-(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-5-(hydroxymethyl)-, hydrochloride (1:2), (2S,3S,4R,5R)- | [CAS]
1373208-51-5 | [Synonyms]
Galidesivir 2HCl
3,4-Pyrrolidinediol, 2-(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-5-(hydroxymethyl)-, hydrochloride (1:2), (2S,3S,4R,5R)- | [Molecular Formula]
C11H16ClN5O3 | [MOL File]
1373208-51-5.mol | [Molecular Weight]
301.73 |
| Hazard Information | Back Directory | [Uses]
Galidesivir (BCX4430; Immucillin-A) dihydrochloride is a broad-spectrum RNA virus inhibitor that can inhibit Ebola and yellow fever virus (Flavivirus) infections. Galidesivir has potent antiviral activity against tick-borne encephalitis virus (TBEV) and also inhibits the proliferation of many other medically important flaviviruses[1]. | [storage]
Store at -20°C | [References]
[1] Eyer L, et al. An E460D Substitution in the NS5 Protein of Tick-Borne Encephalitis Virus Confers Resistance to the Inhibitor Galidesivir (BCX4430) and Also Attenuates the Virus for Mice. J Virol. 2019 Jul 30;93(16):e00367-19. DOI:10.1128/JVI.00367-19 |
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