| Identification | Back Directory | [Name]
Benzeneacetamide, 4-(aminosulfonyl)-N-[3-cyano-5-(cyclohexylmethyl)-4,5,6,7-tetrahydro-6,6-dimethylthieno[3,2-c]pyridin-2-yl]- | [CAS]
2407227-31-8 | [Synonyms]
NITD-688
Benzeneacetamide, 4-(aminosulfonyl)-N-[3-cyano-5-(cyclohexylmethyl)-4,5,6,7-tetrahydro-6,6-dimethylthieno[3,2-c]pyridin-2-yl]- | [Molecular Formula]
C25H32N4O3S2 | [MOL File]
2407227-31-8.mol | [Molecular Weight]
500.68 |
| Hazard Information | Back Directory | [Uses]
NITD-688 is an orally active pan-serotype inhibitor of the dengue virus NS4B protein. NITD-688 can be used in the research of dengue virus (DENV)[1]. | [in vivo]
NITD-688 (30 mg/kg, oral gavage, twice daily for 3 days) demonstrates excellent antiviral efficacy in infected AG129 mice[1].
NITD-688 (15-300 mg/kg, oral gavage, per day for 7 days) is well tolerated in rats and dogs (toxicology studies)[1].
| Animal Model: | Infected AG129 mice[1] | | Dosage: | 30 mg/kg | | Administration: | Oral gavage, twice daily for 3 days | | Result: | Resulted in a 1.16-log reduction in viremia. |
| [References]
[1] Moquin SA, et al. NITD-688, a pan-serotype inhibitor of the dengue virus NS4B protein, shows favorable pharmacokinetics and efficacy in preclinical animal models. Sci Transl Med. 2021 Feb 3;13(579):eabb2181. DOI:10.1126/scitranslmed.abb2181 |
|
|