| Identification | Back Directory | [Name]
4-Cyclopropyl-9-(4-quinolin-7-yl-benzenesulfonyl)-1-oxa-4,9-diaza-spiro[5.5]undecan-3-one | [CAS]
1375105-96-6 | [Synonyms]
FAS-IN-1
FASN-IN-4
4-Cyclopropyl-9-(4-quinolin-7-yl-benzenesulfonyl)-1-oxa-4,9-diaza-spiro[5.5]undecan-3-one
1-Oxa-4,9-diazaspiro[5.5]undecan-3-one, 4-cyclopropyl-9-[[4-(7-quinolinyl)phenyl]sulfonyl]- | [Molecular Formula]
C26H27N3O4S | [MDL Number]
MFCD28411424 | [MOL File]
1375105-96-6.mol | [Molecular Weight]
477.58 |
| Chemical Properties | Back Directory | [Boiling point ]
712.9±70.0 °C(Predicted) | [density ]
1.42±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
3.98±0.14(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
FASN-IN-4 is a potent inhibitor of fatty acid synthase (FASN) with an IC50 of 10 nM (WO2012064642A1, compound 29)[1]. FASN-IN-4 also inhibits SARS-CoV-2 with an EC50 of 18.6?nM[2]. | [References]
[1] Nicholas D. Adams, et al. Fatty acid synthase inhibitors. WO2012064642A1.
[2] Junjun Chu, et al. Pharmacological inhibition of fatty acid synthesis blocks SARS-CoV-2 replication. Nat Metab. 2021 Nov;3(11):1466-1475. DOI:10.1038/s42255-021-00479-4 |
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