| Identification | Back Directory | [Name]
2-[1-(3-Fluoro-phenyl)-cyclohexylamino]-pyrimidine-5-carboxylic acid hydroxyamide | [CAS]
1375466-18-4 | [Synonyms]
ACY-77
ACY-775
CS-2821
ACY-775
(ACY 775
ACY-775; ACY 775; ACY775.
5-Pyrimidinecarboxamide, 2-[[1-(3-fluorophenyl)cyclohexyl]amino]-N-hydroxy-
2-[1-(3-Fluoro-phenyl)-cyclohexylamino]-pyrimidine-5-carboxylic acid hydroxyamide | [Molecular Formula]
C17H19FN4O2 | [MDL Number]
MFCD30533691 | [MOL File]
1375466-18-4.mol | [Molecular Weight]
330.36 |
| Chemical Properties | Back Directory | [density ]
1.342±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Sealed in dry,2-8°C | [solubility ]
DMSO:35.33(Max Conc. mg/mL);106.94(Max Conc. mM)
DMF:20.0(Max Conc. mg/mL);60.54(Max Conc. mM)
DMF:PBS (pH 7.2) (1:4):0.2(Max Conc. mg/mL);0.61(Max Conc. mM)
Ethanol:34.5(Max Conc. mg/mL);104.43(Max Conc. mM) | [form ]
A solid | [pka]
7.74±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
ACY-775 is a novel histone deacetylase 6-selective (HDAC6) inhibitor with antidepressant and pro-cognitive properties. ACY-775 inhibits HDAC6 with low nanomolar potency and a selectivity of 60- to 1500-fold over class I HDACs. | [in vivo]
Biodistribution profiles of ACY-738, ACY-775, and tubastatin A are examined after acute dosing at 5 or 50?mg/kg over 2?h. At t=30?min after acute 50?mg/kg injection, respective plasma levels of ACY-738 and ACY-775 are 515?ng/mL (1.9?μM) and 1359?ng/mL (4.1?μM). Elimination from plasma is rapid, with plasmatic half-life of 12?min and concentration below 10?ng/mL after 2?h. Nevertheless, areas under concentration time curves for brain and plasm calculated over 2?h for both ACY-738 and ACY-775 lead to ratios >1. When ACY-738 (5?mg/kg) or ACY-775 (50?mg/kg) are administered repeatedly in wild-type mice at 24?h, 4?h, and 30?min before killing, significant increases in α-tubulin acetylation are observed in all tested brain regions[2]. | [IC 50]
HDAC6: 7.5 nM (IC50); HDAC1: 2123 nM (IC50); HDAC2: 2570 nM (IC50); HDAC3: 11223 nM (IC50) | [storage]
Store at -20°C |
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| Company Name: |
BOC Sciences
|
| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
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