| Identification | Back Directory | [Name]
6-(4-phenylpiperazin-1-yl)pyridine-3-carboximidamide trihydrochloride | [CAS]
1376162-36-5 | [Synonyms]
6-(4-phenylpiperazin-1-yl)pyridine-3-carboximidamide trihydrochloride | [Molecular Formula]
C16H20ClN5 | [MOL File]
1376162-36-5.mol | [Molecular Weight]
317.82 |
| Hazard Information | Back Directory | [Uses]
C1s-IN-1 trihydrochloride (Compound A1) is the selective inhibitor for C1s protease with the Ki of 5.8 μM. C1s-IN-1 trihydrochloride inhibits cleavage of C2 by C1s with an IC50 of 85 μM, inhibits the activation of classic pathway with an IC50 of 22 μM. C1s-IN-1 trihydrochloride is the competitive inhibitor for thrombin with the Ki of 51.2 μM[1]. | [References]
[1] Xu X, et al., Inhibition of the C1s Protease and the Classical Complement Pathway by 6-(4-Phenylpiperazin-1-yl)Pyridine-3-Carboximidamide and Chemical Analogs. J Immunol. 2024 Feb 15;212(4):689-701. DOI:10.4049/jimmunol.2300630 |
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| Company Name: |
Bide Pharmatech Ltd.
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| Telephone: |
400-1647117 13681763483 |
| Website: |
https://www.bidepharm.com/ |
| Company Name: |
TargetMol
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400-821-0310 15002144251 |
| Website: |
www.targetmol.cn/ |
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