| Identification | Back Directory | [Name]
4-chloro-2-(1H-1,2,3-triazol-4-yl)phenol | [CAS]
1378976-02-3 | [Synonyms]
MMG-0358
4-chloro-2-(1H-1,2,3-trizol-4-y)phenol
4-chloro-2-(1H-1,2,3-triazol-4-yl)phenol | [Molecular Formula]
C8H6ClN3O | [MOL File]
1378976-02-3.mol | [Molecular Weight]
195.61 |
| Chemical Properties | Back Directory | [Boiling point ]
419.0±30.0 °C(Predicted) | [density ]
1.506±0.06 g/cm3(Predicted) | [solubility ]
DMF: 20 mg/ml; DMF:PBS (pH 7.2) (1:4): 0.2 mg/ml; DMSO: 15 mg/ml; Ethanol: 15 mg/ml | [form ]
A solid | [pka]
7.81±0.70(Predicted) |
| Hazard Information | Back Directory | [Description]
MMG-0358 is a novel potent IDO1 inhibitor, showing low cytotoxicity and higher selectivity for IDO1 over TDO enzyme. | [Uses]
MMG-0358 is a potent IDO1 inhibitor. MMG-0358 shows IC50 values of 2 nM in a cellular assay on mIDO1, 80 nM in a cellular assay on hIDO1, 330 nM in an enzymatic assay on hIDO1 at pH 6.5, and 71 nM in an enzymatic assay on hIDO1 at pH 7.4[1]. | [IC 50]
IDO1: 330 nM (IC50) | [References]
[1] R?hrig UF, et al. Rational design of 4-aryl-1,2,3-triazoles for indoleamine 2,3-dioxygenase 1 inhibition. J Med Chem. 2012 Jun 14;55(11):5270-90. DOI:10.1021/jm300260v |
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